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GPCR19

The G protein-coupled bile acid receptor 1 (GPBAR1) also known G-protein coupled receptor 19 (GPCR19), membrane-type receptor for bile acids (M-BAR) or TGR5 as is a protein that in humans is encoded by the GPBAR1 gene.

  • Deoxycholic acid sodium salt
    T5077302-95-4
    Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
    • $38
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  • PEN (human) aceate
    TP1949L
    PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.
    • $148
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  • BAR 501 impurity
    T87521632118-70-7
    BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase activity in a GP-BAR1 reporter gene assay
    • $133
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    TargetMol | Inhibitor Sale
  • INT-777
    T11662L1199796-29-6In house
    INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
    • $139
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  • Ursodeoxycholic acid sodium
    T290782898-95-5In house
    Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors,
    • $118
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  • Deoxycholic acid
    T296583-44-3
    Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
    • $53
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    TargetMol | Citations Cited
  • Hyodeoxycholic acid
    T296883-49-8
    Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
    • $38
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    TargetMol | Citations Cited
  • INT-767
    T116611000403-03-1
    INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.
    • $399
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  • Triamterene
    T0843396-01-0
    Triamterene is a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.
    • $37
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  • BAR502
    TQ02521612191-86-2
    BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
    • $107
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  • TC-G 1005
    T88181415407-60-1
    TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
    • $30
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  • SBI-115
    T7428882366-16-7
    SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
    • $48
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  • TGR5 Receptor Agonist
    T18241197300-24-5
    TGR5 is a potent TGR5(GPCR19) agonist.
    • $34
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  • L-692429
    T11798145455-23-8
    L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by glucocorticoids.L-692429 has a high affinity for the G protein-coupled receptor and can be used in the study of acromegaly and obesity. L-692429 has a high affinity for G protein-coupled receptor and can be used to study acromegaly and obesity.
    • $158
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  • BAR501
    T40831632118-69-4
    BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).
    • $57
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  • SB756050
    T4352447410-57-3
    SB756050 is a specific TGR5 agonist.
    • $35
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    TargetMol | Inhibitor Sale