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Mps1-IN-1

Name: Mps1-IN-1
Brand: TargetMol
SKU: T12102
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12102Cas No. 1125593-20-5

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Mps1-IN-1

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Purity: 99.55%

Catalog No. T12102Cas No. 1125593-20-5

Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$90	In Stock	In Stock
10 mg	$169	In Stock	In Stock
25 mg	$333	In Stock	In Stock
50 mg	$498	In Stock	In Stock
100 mg	$723	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.55%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM).
Targets&IC50	CLK1:1900 nM (kd), PYK2:280 nM (kd), TNK1:2600 nM (kd), ERK2:2900 nM (kd), Insulin receptor:470 nM (kd), Mps1:27 nM (kd), GAK:1100 nM (kd), TNK2:3100 nM (kd), Insulin receptor related receptor:1200 nM (kd), IGF-1R:750 nM (kd), FAK:440 nM (kd), Mps1:367 nM, ALK:21 nM (kd), TYK1/LTK:29 nM (kd)
In vitro	Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase with IC50 and Kd values of 367 nM and 27 nM, respectively. It also exhibits high affinity for ALK and LTK, with Kd values of 21 nM and 39 nM, respectively[1].

Chemical Properties

Molecular Weight	535.66
Formula	C₂₈H₃₃N₅O₄S
Cas No.	1125593-20-5
Smiles	COc1cc(ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1)N1CCC(O)CC1
Relative Density.	1.354 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 39 mg/mL (72.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8669 mL	9.3343 mL	18.6686 mL	93.3428 mL
5 mM	0.3734 mL	1.8669 mL	3.7337 mL	18.6686 mL
10 mM	0.1867 mL	0.9334 mL	1.8669 mL	9.3343 mL
20 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6671 mL
50 mM	0.0373 mL	0.1867 mL	0.3734 mL	1.8669 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc