Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

WEHI-539 hydrochloride

Name: WEHI-539 hydrochloride
Brand: TargetMol
SKU: T13337
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T13337Cas No. 2070018-33-4

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.

WEHI-539 hydrochloride

🥰Excellent

Catalog No. T13337Cas No. 2070018-33-4

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Resource Download

Product Introduction

Bioactivity

Description	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.
Targets&IC50	BCL-XL:1.1 nM
In vitro	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor that enhances NSC 241240-induced caspase 3/7 activity, PARP cleavage, and annexin V labeling. As a single agent, WEHI-539 induces significant PARP cleavage in Ovcar-4 (5 μM in Ovcar-4) and Ovsaho (1 μM in Ovsaho) cells[2].

Chemical Properties

Molecular Weight	620.18
Formula	C₃₁H₃₀ClN₅O₃S₂
Cas No.	2070018-33-4
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (80.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.03 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6124 mL	8.0622 mL	16.1244 mL	80.6218 mL
5 mM	0.3225 mL	1.6124 mL	3.2249 mL	16.1244 mL
10 mM	0.1612 mL	0.8062 mL	1.6124 mL	8.0622 mL
20 mM	0.0806 mL	0.4031 mL	0.8062 mL	4.0311 mL
50 mM	0.0322 mL	0.1612 mL	0.3225 mL	1.6124 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc