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WEHI-539 hydrochloride

Name: WEHI-539 hydrochloride
Brand: TargetMol
SKU: T13337
Rating: 4.5 (1 reviews)

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Catalog No. T13337Cas No. 2070018-33-4

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.

WEHI-539 hydrochloride

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🥰Excellent

Catalog No. T13337Cas No. 2070018-33-4

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.

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Product Introduction

Bioactivity

Description	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.
Targets&IC50	BCL-XL:1.1 nM
In vitro	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor that enhances NSC 241240-induced caspase 3/7 activity, PARP cleavage, and annexin V labeling. As a single agent, WEHI-539 induces significant PARP cleavage in Ovcar-4 (5 μM in Ovcar-4) and Ovsaho (1 μM in Ovsaho) cells[2].

Chemical Properties

Molecular Weight	620.18
Formula	C₃₁H₃₀ClN₅O₃S₂
Cas No.	2070018-33-4
Smiles	Cl.NCc1ccc(OCCCc2sc(nc2C(O)=O)-c2ccc3CCC\C(=N/Nc4nc5ccccc5s4)c3c2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (80.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (4.03 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6124 mL	8.0622 mL	16.1244 mL	80.6218 mL
5 mM	0.3225 mL	1.6124 mL	3.2249 mL	16.1244 mL
10 mM	0.1612 mL	0.8062 mL	1.6124 mL	8.0622 mL
20 mM	0.0806 mL	0.4031 mL	0.8062 mL	4.0311 mL
50 mM	0.0322 mL	0.1612 mL	0.3225 mL	1.6124 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc