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KMCA-0011
Catalog No. T213806 Copy Product Info
🥰Excellent
KMCA-0011 is an orally active antagonist of the ɑ2C adrenoceptor (Ki= 56.7 nM). It alleviates depressive behavior by enhancing brain-derived neurotrophic factor (BDNF) and synaptic plasticity. KMCA-0011 demonstrates excellent metabolic stability, maintaining 99.8% plasma stability after 120 minutes. It is a useful compound for researching depression.
KMCA-0011
Copy Product Info🥰Excellent
Catalog No. T213806
KMCA-0011 is an orally active antagonist of the ɑ2C adrenoceptor (Ki= 56.7 nM). It alleviates depressive behavior by enhancing brain-derived neurotrophic factor (BDNF) and synaptic plasticity. KMCA-0011 demonstrates excellent metabolic stability, maintaining 99.8% plasma stability after 120 minutes. It is a useful compound for researching depression.
KMCA-0011
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | KMCA-0011 is an orally active antagonist of the ɑ2C adrenoceptor (Ki= 56.7 nM). It alleviates depressive behavior by enhancing brain-derived neurotrophic factor (BDNF) and synaptic plasticity. KMCA-0011 demonstrates excellent metabolic stability, maintaining 99.8% plasma stability after 120 minutes. It is a useful compound for researching depression. |
| Targets&IC50 | α2C-adrenoceptor:56.7 nM (Ki) |
| In vitro | KMCA-0011 (Compound 11e) demonstrates significant high binding affinity for ɑ2C adrenoceptors in human HEK-293 cells (K i = 56.7 nM). At a concentration of 10 μM, KMCA-0011 effectively inhibits adrenaline-induced ERK phosphorylation. |
| In vivo | KMCA-0011 (Compound 11e), administered orally at a dosage of 1-10 mg/kg once daily for one week, consistently demonstrated therapeutic efficacy across several tests. It uniquely reduced anxiety-like behavior in the EPM test, enhanced hippocampal BDNF expression, and restored CORT-induced synaptic plasticity impairments in the mother-offspring separation (MS) mouse model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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