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VU0405601

🥰Excellent
Catalog No. T29131Cas No. 712325-30-9
Alias VU 0405601

VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.

VU0405601

VU0405601

🥰Excellent
Purity: 99.16%
Catalog No. T29131Alias VU 0405601Cas No. 712325-30-9
VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
Pack SizePriceAvailabilityQuantity
1 mg$94In Stock
5 mg$233In Stock
10 mg$373In Stock
25 mg$673In Stock
50 mg$939In Stock
100 mg$1,260In Stock
200 mg$1,680In Stock
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Purity:99.16%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
In vitro
VU0405601 (5 µM, pretreated for 30 minutes before dofetilide) protects rabbit cardiac tissue from dofetilide-induced ventricular tachycardia. [1]
SynonymsVU 0405601
Chemical Properties
Molecular Weight357.2
FormulaC17H13BrN2O2
Cas No.712325-30-9
SmilesO=C(NC=1C=NC=CC1)COC=2C=CC=3C=CC=CC3C2Br
Relative Density.1.523 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (223.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7996 mL13.9978 mL27.9955 mL139.9776 mL
5 mM0.5599 mL2.7996 mL5.5991 mL27.9955 mL
10 mM0.2800 mL1.3998 mL2.7996 mL13.9978 mL
20 mM0.1400 mL0.6999 mL1.3998 mL6.9989 mL
50 mM0.0560 mL0.2800 mL0.5599 mL2.7996 mL
100 mM0.0280 mL0.1400 mL0.2800 mL1.3998 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

VU-0405601VU0405601
Related Tags: buy VU0405601 | purchase VU0405601 | VU0405601 cost | order VU0405601 | VU0405601 chemical structure | VU0405601 in vitro | VU0405601 formula | VU0405601 molecular weight
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