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VU0405601

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Catalog No. T29131Cas No. 712325-30-9

Alias VU 0405601

VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.

VU0405601

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Purity: 99.16%

Catalog No. T29131Alias VU 0405601Cas No. 712325-30-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$94	-	In Stock
5 mg	$233	-	In Stock
10 mg	$373	-	In Stock
25 mg	$673	-	In Stock
50 mg	$939	-	In Stock
100 mg	$1,260	-	In Stock
200 mg	$1,680	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.16%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
In vitro	VU0405601 (5 µM, pretreated for 30 minutes before dofetilide) protects rabbit cardiac tissue from dofetilide-induced ventricular tachycardia. [1]
Synonyms	VU 0405601

Chemical Properties

Molecular Weight	357.2
Formula	C₁₇H₁₃BrN₂O₂
Cas No.	712325-30-9
Smiles	O=C(NC=1C=NC=CC1)COC=2C=CC=3C=CC=CC3C2Br
Relative Density.	1.523 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (223.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7996 mL	13.9978 mL	27.9955 mL	139.9776 mL
5 mM	0.5599 mL	2.7996 mL	5.5991 mL	27.9955 mL
10 mM	0.2800 mL	1.3998 mL	2.7996 mL	13.9978 mL
20 mM	0.1400 mL	0.6999 mL	1.3998 mL	6.9989 mL
50 mM	0.0560 mL	0.2800 mL	0.5599 mL	2.7996 mL
100 mM	0.0280 mL	0.1400 mL	0.2800 mL	1.3998 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc