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VU0405601

Name: VU0405601
Brand: TargetMol
SKU: T29131
Price: 94 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29131Cas No. 712325-30-9

Alias VU 0405601

VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.

VU0405601

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Purity: 99.16%

Catalog No. T29131Alias VU 0405601Cas No. 712325-30-9

Pack Size	Price	Availability
1 mg	$94	In Stock
5 mg	$233	In Stock
10 mg	$373	In Stock
25 mg	$673	In Stock
50 mg	$939	In Stock
100 mg	$1,260	In Stock
200 mg	$1,680	In Stock

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Batch Information

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Purity:99.16%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
In vitro	VU0405601 (5 µM, pretreated for 30 minutes before dofetilide) protects rabbit cardiac tissue from dofetilide-induced ventricular tachycardia. [1]
Synonyms	VU 0405601

Chemical Properties

Molecular Weight	357.2
Formula	C₁₇H₁₃BrN₂O₂
Cas No.	712325-30-9
Smiles	O=C(NC=1C=NC=CC1)COC=2C=CC=3C=CC=CC3C2Br
Relative Density.	1.523 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (223.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7996 mL	13.9978 mL	27.9955 mL	139.9776 mL
5 mM	0.5599 mL	2.7996 mL	5.5991 mL	27.9955 mL
10 mM	0.2800 mL	1.3998 mL	2.7996 mL	13.9978 mL
20 mM	0.1400 mL	0.6999 mL	1.3998 mL	6.9989 mL
50 mM	0.0560 mL	0.2800 mL	0.5599 mL	2.7996 mL
100 mM	0.0280 mL	0.1400 mL	0.2800 mL	1.3998 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc