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VU0405601
🥰Excellent
Catalog No. T29131Cas No. 712325-30-9
Alias VU 0405601
VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
VU0405601
🥰Excellent
Purity: 99.16%
Catalog No. T29131Alias VU 0405601Cas No. 712325-30-9
VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $94 | - | In Stock | |
| 5 mg | $233 | - | In Stock | |
| 10 mg | $373 | - | In Stock | |
| 25 mg | $673 | - | In Stock | |
| 50 mg | $939 | - | In Stock | |
| 100 mg | $1,260 | - | In Stock | |
| 200 mg | $1,680 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.16%
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Product Introduction
Bioactivity
Chemical Properties
| Description | VU0405601 is a potent pharmacological activator of the KV11.1 channel (hERG) that functions as a hERG agonist, thereby protecting cardiac tissue against arrhythmias and ventricular tachycardia induced by other hERG-inhibiting compounds such as Dofetilide. |
| In vitro | VU0405601 (5 µM, pretreated for 30 minutes before dofetilide) protects rabbit cardiac tissue from dofetilide-induced ventricular tachycardia. [1] |
| Synonyms | VU 0405601 |
| Molecular Weight | 357.2 |
| Formula | C17H13BrN2O2 |
| Cas No. | 712325-30-9 |
| Smiles | O=C(NC=1C=NC=CC1)COC=2C=CC=3C=CC=CC3C2Br |
| Relative Density. | 1.523 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (223.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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