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(-)-Epigallocatechin Gallate

Name: (-)-Epigallocatechin Gallate
Brand: TargetMol
SKU: T2988
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2988Cas No. 989-51-5

Alias Epigallocatechol Gallate, EGCG

(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.

(-)-Epigallocatechin Gallate

🥰Excellent

Purity: 99.43%

Catalog No. T2988Alias Epigallocatechol Gallate, EGCGCas No. 989-51-5

Pack Size	Price	Availability
50 mg	$43	In Stock
100 mg	$57	In Stock
500 mg	$138	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock

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Purity:99.43%

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Product Introduction

Bioactivity

Description	(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
Targets&IC50	SK-MEL-2 cells:31 μM, HeLa cells:1.08 μM, MDCK cells:41.25 μM, CHO cells:3.2 μM, A549 cells:29 μM, 3T3-L1 cells:112 μM, SW48 cells:195 μM, BxPC-3 cells:33 μM, L929 cells:82.3 μM, HT22 cells:23.8 μM, NCI-H1299 cells:20.6 μM, HSCT6 cells:9.9 μM, COLO 201 cells:38 μM, HCT116 cells:5 μM, Jurkat cells:1 μM
In vitro	METHODS: Human thyroid cancer cells TT, TPC-1 and ARO were treated with (-)-Epigallocatechin Gallate (10-200 µM) for 24 h. Cell viability was detected using MTS assay.
In vivo	METHODS: To investigate the protective effect against acute injury, (-)-Epigallocatechin Gallate (200 mg/kg) was administered to ICR mice by gavage once a day for one week, followed by intraperitoneal injection of LPS (15 mg/kg) to induce acute injury. RESULTS: (-)-Epigallocatechin Gallate protects mice from LPS-induced acute stress, while stabilizing gut microorganisms, improving sphingolipid metabolism, and inhibiting harmful metabolite levels. [3]
Cell Research	LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100.
Synonyms	Epigallocatechol Gallate, EGCG

Chemical Properties

Molecular Weight	458.37
Formula	C₂₂H₁₈O₁₁
Cas No.	989-51-5
Smiles	O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4
Relative Density.	1.9g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (529.05 mM), Sonication is recommended.

H2O: 50 mg/mL (109.08 mM), Sonication is recommended.

Ethanol: 45.8 mg/mL (99.92 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1816 mL	10.9082 mL	21.8164 mL	109.0822 mL
5 mM	0.4363 mL	2.1816 mL	4.3633 mL	21.8164 mL
10 mM	0.2182 mL	1.0908 mL	2.1816 mL	10.9082 mL
20 mM	0.1091 mL	0.5454 mL	1.0908 mL	5.4541 mL
50 mM	0.0436 mL	0.2182 mL	0.4363 mL	2.1816 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0218 mL	0.1091 mL	0.2182 mL	1.0908 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc