Shopping Cart

Your shopping cart is currently empty

(-)-Epigallocatechin Gallate

Name: (-)-Epigallocatechin Gallate
Brand: TargetMol
SKU: T2988
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T2988Cas No. 989-51-5

Alias Epigallocatechol Gallate, EGCG

(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.

(-)-Epigallocatechin Gallate

Copy Product Info

🥰Excellent

Purity: 99.99%

Catalog No. T2988Alias Epigallocatechol Gallate, EGCGCas No. 989-51-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$43	In Stock	In Stock
100 mg	$57	In Stock	In Stock
500 mg	$138	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.99%

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	(-)-Epigallocatechin Gallate (EGCG) is a phenolic antioxidant polyphenol flavonoid found in plants such as green and black tea, which inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits cellular oxidation, and prevents free radical damage to cells.
Targets&IC50	HeLa cells:1.08 μM, HCT116 cells:5 μM, CHO cells:3.2 μM, SK-MEL-2 cells:31 μM, A549 cells:29 μM, 3T3-L1 cells:112 μM, COLO 201 cells:38 μM, HT22 cells:23.8 μM, MDCK cells:41.25 μM, NCI-H1299 cells:20.6 μM, BxPC-3 cells:33 μM, Jurkat cells:1 μM, HSCT6 cells:9.9 μM, L929 cells:82.3 μM, SW48 cells:195 μM
In vitro	METHODS: Human thyroid cancer cells TT, TPC-1 and ARO were treated with (-)-Epigallocatechin Gallate (10-200 µM) for 24 h. Cell viability was detected using MTS assay.
In vivo	METHODS: To investigate the protective effect against acute injury, (-)-Epigallocatechin Gallate (200 mg/kg) was administered to ICR mice by gavage once a day for one week, followed by intraperitoneal injection of LPS (15 mg/kg) to induce acute injury. RESULTS: (-)-Epigallocatechin Gallate protects mice from LPS-induced acute stress, while stabilizing gut microorganisms, improving sphingolipid metabolism, and inhibiting harmful metabolite levels. [3]
Cell Research	LoVo, SW480, HCT-8, and HT-29 cells are seeded in 96-well plates at a concentration of 5×103?cells; each cell line is totally seeded in the 12 wells. Complete medium is added to the wells, up to 200 μL; the medium contains 0 μg/mL, 10 μg/mL, 20 μg/mL, and 35 μg/mL of epigallocatechol gallate. The inhibition rate=[1 - (absorbance of Epigallocatechol Gallate group - absorbance of control group)/(absorbance of control group - absorbance of blank control group)] × 100.
Synonyms	Epigallocatechol Gallate, EGCG

Chemical Properties

Molecular Weight	458.37
Formula	C₂₂H₁₈O₁₁
Cas No.	989-51-5
Smiles	O(C(=O)C1=CC(O)=C(O)C(O)=C1)[C@H]2[C@H](OC=3C(C2)=C(O)C=C(O)C3)C4=CC(O)=C(O)C(O)=C4
Relative Density.	1.9g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (529.05 mM), Sonication is recommended.

H2O: 50 mg/mL (109.08 mM), Sonication is recommended.

Ethanol: 45.8 mg/mL (99.92 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1816 mL	10.9082 mL	21.8164 mL	109.0822 mL
5 mM	0.4363 mL	2.1816 mL	4.3633 mL	21.8164 mL
10 mM	0.2182 mL	1.0908 mL	2.1816 mL	10.9082 mL
20 mM	0.1091 mL	0.5454 mL	1.0908 mL	5.4541 mL
50 mM	0.0436 mL	0.2182 mL	0.4363 mL	2.1816 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0218 mL	0.1091 mL	0.2182 mL	1.0908 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc