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Timonacic
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Catalog No. T0221Cas No. 444-27-9
Alias Thioproline, Thiazolidine-4-carboxylic acid, Hepalidine, Detoxepa, 1,3-Thiazolidine-4-carboxylic acid
Timonacic (Thioproline) has been used in trials studying the treatment of HIV Infections.
Timonacic
Copy Product Info🥰Excellent
Purity: 99.99%
Catalog No. T0221Alias Thioproline, Thiazolidine-4-carboxylic acid, Hepalidine, Detoxepa, 1,3-Thiazolidine-4-carboxylic acidCas No. 444-27-9
Timonacic (Thioproline) has been used in trials studying the treatment of HIV Infections.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $29 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $52 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.99%
Appearance:Solid
Color:White
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Product Introduction
Timonacic AI Summary
Timonacic demonstrates multiple bioactivities, including potential liver protection and antiviral properties. It significantly reduces acetaminophen-induced liver necrosis in mice after 3 hours but shows hepatotoxicity at high doses, with an LD50 value of 164.0 mg/kg. The compound has relatively low inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), with an inhibition index of 0.2679, and demonstrates 2.46% inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration over 48 hours. Additionally, it exhibits antiviral efficacy against SARS-CoV-2 (USA-WA1/2020 strain) in HRCE cells with a hit score of 0.2596 and SARS-CoV-2 3CL-Pro protease inhibition with 20.29% and 12.17% inhibition at 20 μM. Furthermore, it shows minimal inhibitory effects on VERO-6 cells' SARS-CoV-2 induced cytotoxicity, ranging from -0.06% to -0.14% at 10 μM. Lastly, Timonacic inhibits human HDAC6 enzymatic activity with inhibition percentages of 8.04% and 10.17% using different peptide substrates..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Timonacic (Thioproline) has been used in trials studying the treatment of HIV Infections. |
| Synonyms | Thioproline, Thiazolidine-4-carboxylic acid, Hepalidine, Detoxepa, 1,3-Thiazolidine-4-carboxylic acid |
| Molecular Weight | 133.17 |
| Formula | C4H7NO2S |
| Cas No. | 444-27-9 |
| Smiles | OC(=O)C1CSCN1 |
| Relative Density. | 1.226 g/cm3 (Estimated) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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