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Anti-NEK6 Antibody (1W434)
😃Good
Catalog No. TMAB-09348
Anti-NEK6 Antibody (1W434) is a Rabbit antibody targeting NEK6. Anti-NEK6 Antibody (1W434) can be used in WB,IP.
Anti-NEK6 Antibody (1W434)
Anti-NEK6 Antibody (1W434)
😃Good
Catalog No. TMAB-09348
Anti-NEK6 Antibody (1W434) is a Rabbit antibody targeting NEK6. Anti-NEK6 Antibody (1W434) can be used in WB,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $264 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NEK6 Antibody (1W434) is a Rabbit antibody targeting NEK6. Anti-NEK6 Antibody (1W434) can be used in WB,IP. |
| Ig Type | IgG |
| Clone | 1W434 |
| Reactivity | Human,Rat (predicted:Mouse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Nucleus speckle. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Co-localizes with APBB1 at the nuclear speckles. Co-localizes with PIN1 in the nucleus. Co-localizes with ATF4, CIR1, ARHGAP33, ANKRA2, CDC42, NEK9, RAD26L, RBBP6, RPS7, TRIP4, RELB and PHF1 in the centrosome. Localizes to spindle microtubules in metaphase and anaphase and to the midbody during cytokinesis. [ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9HC98-1; Sequence=Displayed; Name=2; IsoId=Q9HC98-2; Sequence=VSP_041798; Name=3; IsoId=Q9HC98-3; Sequence=VSP_041799; Name=4; IsoId=Q9HC98-4; Sequence=VSP_041800. |
| Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. Up-regulated in a variety of malignant cancers, such as breast, colon, lung, and gastric cancers. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Protein kinase which plays an important role in mitotic cell cycle progression.Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis.Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. |
| Immunogen | A synthesized peptide: human NEK6 |
| Antigen Species | Human |
| Gene Name | NEK6 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase Nek6 |
| Uniprot ID | |
| Function | Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence. |
| Molecular Weight | Theoretical: 36 kDa. Actual: 28 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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