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CYPA Protein, Human, Recombinant
(Synonyms: SP18, Rotamase A, PPIase A, PPIA, Peptidyl-prolyl cis-trans isomerase A, CYPA, Cyclosporin A-binding protein, Cyclophilin A) Copy Product InfoSynonyms: SP18, Rotamase A, PPIase A, PPIA, Peptidyl-prolyl cis-trans isomerase A, CYPA, Cyclosporin A-binding protein, Cyclophilin A
Catalog No. TMPJ-01049 Copy Product Info
Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 μg | $35 | 7-10 days | 7-10 days | |
| 20 μg | $55 | 7-10 days | 7-10 days | |
| 50 μg | $110 | 7-10 days | 7-10 days | |
| 100 μg | $192 | 7-10 days | 7-10 days | |
| 200 μg | $342 | 7-10 days | 7-10 days | |
| 500 μg | $745 | 7-10 days | 7-10 days | |
| 1 mg | $1,180 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Solution
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity. |
| Species | Human |
| Expression System | E. coli |
| Tag | Tag Free |
| Accession Number | P62937 |
| Amino Acid | Met1-Glu165 |
| Construction | Met1-Glu165 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | SP18, Rotamase A, PPIase A, PPIA, Peptidyl-prolyl cis-trans isomerase A, CYPA, Cyclosporin A-binding protein, Cyclophilin A |
| Research Background |
| Molecular Weight | 16 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: CYPA Protein, Human, Recombinant chemical structure | CYPA Protein, Human, Recombinant molecular weight
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