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CP-312

🥰Excellent
Catalog No. T27064Cas No. 895470-67-4
Alias CP312, Cardioprotectant 312

CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting through induction of heme oxygenase-1 and targeting the antioxidant response network by inducing HMOX1 expression.CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress.

CP-312

CP-312

🥰Excellent
Purity: 99.61%
Catalog No. T27064Alias CP312, Cardioprotectant 312Cas No. 895470-67-4
CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting through induction of heme oxygenase-1 and targeting the antioxidant response network by inducing HMOX1 expression.CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress.
Pack SizePriceAvailabilityQuantity
1 mg$45In Stock
5 mg$106In Stock
10 mg$158In Stock
25 mg$289In Stock
50 mg$428In Stock
100 mg$591In Stock
500 mg$1,270In Stock
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Purity:99.61%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting through induction of heme oxygenase-1 and targeting the antioxidant response network by inducing HMOX1 expression.CP-312 protects human iPSC-derived cardiomyocytes from oxidative stress.
In vitro
CP-312 (10 µM; 2 h) demonstrated significant efficacy in protecting hiPSC-CM from acute peroxide-induced cell death, with an EC50 of 6.7 µM.[1]
SynonymsCP312, Cardioprotectant 312
Chemical Properties
Molecular Weight361.87
FormulaC16H12ClN3OS2
Cas No.895470-67-4
SmilesClC1=CC=C(SCC(=O)NC2=NC(=CS2)C2=CC=CC=N2)C=C1
Relative Density.1.45 g/cm3 (Predicted)
ColorRed
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (124.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7634 mL13.8171 mL27.6342 mL138.1712 mL
5 mM0.5527 mL2.7634 mL5.5268 mL27.6342 mL
10 mM0.2763 mL1.3817 mL2.7634 mL13.8171 mL
20 mM0.1382 mL0.6909 mL1.3817 mL6.9086 mL
50 mM0.0553 mL0.2763 mL0.5527 mL2.7634 mL
100 mM0.0276 mL0.1382 mL0.2763 mL1.3817 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

ReactiveOxygenSpeciesReactive Oxygen SpeciesCP-312CP 312(HO)-1
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