Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,140.00 | |
50 mg | 10-14 weeks | $ 1,490.00 | |
100 mg | 10-14 weeks | $ 2,280.00 |
Description | NBI-31772 hydrate is a powerful inhibitor of the interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). It acts as a nonpeptide ligand, effectively releasing bioactive IGF-I from the IGF-I/IGFBP-3 complex (Ki values for all six human subtypes range from 1-24 nM). This compound demonstrates significant anxiolytic and antidepressant-like effects [1] [2] [3]. |
In vivo | NBI-31772 administered intracerebroventricularly (icv) in doses ranging from 5 to 100 μg to Sprague-Dawley rats subjected to the subtemporal middle cerebral artery occlusion (MCAO) model, either immediately or up to 3 hours post-MCAO, dose-dependently mitigated infarct size. Specifically, the maximum dose of 100 μg significantly diminished both overall and cortical infarct volumes, showcasing its protective efficacy against ischemic brain injury [3]. |
Molecular Weight | 372.82 |
Formula | C17H13NO8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NBI-31772 hydrate inhibitor inhibit