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QPX7728-OH disodium

Name: QPX7728-OH disodium
Brand: TargetMol
SKU: T12603
Price: 417 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12603Cas No. 2170848-99-2

Alias Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodium

QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.

QPX7728-OH disodium

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Catalog No. T12603Alias Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodiumCas No. 2170848-99-2

QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$417	In Stock	In Stock
5 mg	$988	In Stock	In Stock
10 mg	$1,330	In Stock	In Stock
25 mg	$1,980	-	In Stock
50 mg	$2,670	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:>99.99%

ee:99.92%

Appearance:Solid

Color:Brown

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COA CSFC HNMR IC LCMS

Product Introduction

Bioactivity

Description	QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases with antibacterial activity, used in research on bacterial infections.
In vitro	The efficacy of QPX7728 disodium against Pseudomonas aeruginosa was not affected by the OprD inactivation of carbapenem porins. In strains with porin mutations, QPX7728 disodium (4 μg/ml) completely reversed KPC-mediated meropenem resistance. [1] The combination of QPX7728 disodium and cefbutin had similar efficacy against all enzyme subgroups (MIC90 of 1-2 μg/mL). [2]
In vivo	In a neutropenic mouse model of thigh infection, QPX7728 disodium (12.5, 25, or 50 mg/kg intraperitoneally administered every 2 hours for 24h) was administered in combination with cephalosporins. The bacterial counts of two carbapenem-resistant Klebsiella pneumoniae strains were reduced by about 2 log CFU. [[3]
Synonyms	Xeruborbactam disodium, QPX7728-OH disodium, QPX 7728 disodium, OMNIvance, BRII-636 disodium, BRII636 disodium

Chemical Properties

Molecular Weight	283.96
Formula	C₁₀H₈BFNa₂O₅
Cas No.	2170848-99-2
Smiles	[O-]C(C1=C2C([C@@]3([C@@]([H])(C3)[B-](O2)(O)O)[H])=CC=C1F)=O.[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 60 mg/mL (211.3 mM), Sonication is recommended.

DMSO: 80 mg/mL (281.73 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5216 mL	17.6081 mL	35.2162 mL	176.0811 mL
5 mM	0.7043 mL	3.5216 mL	7.0432 mL	35.2162 mL
10 mM	0.3522 mL	1.7608 mL	3.5216 mL	17.6081 mL
20 mM	0.1761 mL	0.8804 mL	1.7608 mL	8.8041 mL
50 mM	0.0704 mL	0.3522 mL	0.7043 mL	3.5216 mL
100 mM	0.0352 mL	0.1761 mL	0.3522 mL	1.7608 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc