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Isatoribine

Name: Isatoribine
Brand: TargetMol
SKU: T24178
Price: 258 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24178Cas No. 122970-40-5

Alias Isatoribine free base, Immusine, ANA-245, ANA245, ANA 245

Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.

Isatoribine

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Purity: 99.75%

Catalog No. T24178Alias Isatoribine free base, Immusine, ANA-245, ANA245, ANA 245Cas No. 122970-40-5

Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$258	In Stock	In Stock
5 mg	$642	In Stock	In Stock
10 mg	$913	In Stock	In Stock
25 mg	$1,370	In Stock	In Stock
50 mg	$1,850	In Stock	In Stock
100 mg	$2,500	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.75%

ee:100%

Appearance:Solid

Color:White

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COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Isatoribine(ANA245) free base is a potent TLR7 receptor agonist with anti-hepatitis C virus infection activity for the study of HCV infection.
In vivo	Isatoribine is a selective agonist of TLR7. In a proof-of-concept study, we found that once-daily 7-day treatment with intravenous Isatoribine 800 mg caused a significant (P = .001) reduction of plasma HCV RNA (mean, -0.76; range, -2.85 to +0.21 log(10) units) in otherwise untreated patients (n = 12) who were chronically infected with HCV. Viral load reduction occurred in patients infected with genotype 1 as well as non-genotype 1 HCV. The reduction of viral load was correlated with the induction of markers of a heightened immune antiviral state, including 2'-, 5'- oligoadenylate synthetase levels in whole blood. This treatment was well tolerated, with a low frequency of mild to moderate adverse events. In conclusion, systemic administration of the selective TLR7 agonist Isatoribine resulted in dose-dependent changes in immunologic biomarkers and a statistically significant antiviral effect with relatively few and mild side effects.[1]
Synonyms	Isatoribine free base, Immusine, ANA-245, ANA245, ANA 245

Chemical Properties

Molecular Weight	316.29
Formula	C₁₀H₁₂N₄O₆S
Cas No.	122970-40-5
Smiles	O=C1N(C2=C(S1)C(=O)N=C(N)N2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
Relative Density.	2.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (142.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1617 mL	15.8083 mL	31.6166 mL	158.0828 mL
5 mM	0.6323 mL	3.1617 mL	6.3233 mL	31.6166 mL
10 mM	0.3162 mL	1.5808 mL	3.1617 mL	15.8083 mL
20 mM	0.1581 mL	0.7904 mL	1.5808 mL	7.9041 mL
50 mM	0.0632 mL	0.3162 mL	0.6323 mL	3.1617 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	1.5808 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc