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Terbuthylazine

Name: Terbuthylazine
Brand: TargetMol
SKU: T13127
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13127Cas No. 5915-41-3

Terbuthylazine is a triazine herbicide and a selective acetolactate synthase (ALS) inhibitor, toxic to aquatic organisms, and capable of disrupting gut microbiota. Terbuthylazine induces significant damage to the jejunal barrier and mitochondrial quality control imbalance.

Terbuthylazine

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Purity: 99.07%

Catalog No. T13127Cas No. 5915-41-3

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	-	In Stock
100 mg	$47	-	In Stock
1 mL x 10 mM (in DMSO)	$52	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.07%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Terbuthylazine is a triazine herbicide and a selective acetolactate synthase (ALS) inhibitor, toxic to aquatic organisms, and capable of disrupting gut microbiota. Terbuthylazine induces significant damage to the jejunal barrier and mitochondrial quality control imbalance.
In vitro	Terbuthylazine induces innate immune response and inflammation by activating the cGAS-STING/NF-κB pathway in broiler heart muscle. [1] Terbuthylazine exposure activates the Nrf2/HO-1 pathway, leading to iron death. [2]
In vivo	Terbuthylazine (0.4 mg/kg) exposure caused cardiomyopathic rational changes in broilers. [1] Terbuthylazine (0.4 or 4 mg/kg, 28 days) broilers showed pathological damage such as widening of interstitial space, breaking of muscle fibers, and deposition of myocardial collagen fibers. [2]

Chemical Properties

Molecular Weight	229.71
Formula	C₉H₁₆ClN₅
Cas No.	5915-41-3
Smiles	ClC=1N=C(N=C(N1)NC(C)(C)C)NCC
Relative Density.	1.1880 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (174.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (8.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3533 mL	21.7666 mL	43.5332 mL	217.6658 mL
5 mM	0.8707 mL	4.3533 mL	8.7066 mL	43.5332 mL
10 mM	0.4353 mL	2.1767 mL	4.3533 mL	21.7666 mL
20 mM	0.2177 mL	1.0883 mL	2.1767 mL	10.8833 mL
50 mM	0.0871 mL	0.4353 mL	0.8707 mL	4.3533 mL
100 mM	0.0435 mL	0.2177 mL	0.4353 mL	2.1767 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc