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USP5-IN-1

🥰Excellent
Catalog No. T60130

USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor that binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. Additionally, USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate [1].

USP5-IN-1

USP5-IN-1

🥰Excellent
Purity: 99.76%
Catalog No. T60130
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor that binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. Additionally, USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$80In StockIn Stock
5 mg$247In StockIn Stock
10 mg$372In StockIn Stock
25 mg$788In StockIn Stock
50 mg$1,080In StockIn Stock
100 mg$1,480-In Stock
500 mg$2,970-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.76%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor that binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. Additionally, USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate [1].
Chemical Properties
Molecular Weight437.9
FormulaC19H20ClN3O5S
SmilesO=C(O)CNC(=O)C1=CC=C(S(=O)(=O)N2CCC(C3=CC=C(Cl)C=C3)CC2)C=N1
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (256.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2836 mL11.4181 mL22.8363 mL114.1813 mL
5 mM0.4567 mL2.2836 mL4.5673 mL22.8363 mL
10 mM0.2284 mL1.1418 mL2.2836 mL11.4181 mL
20 mM0.1142 mL0.5709 mL1.1418 mL5.7091 mL
50 mM0.0457 mL0.2284 mL0.4567 mL2.2836 mL
100 mM0.0228 mL0.1142 mL0.2284 mL1.1418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

USP5-IN-1USP5IN1USP5
Related Tags: buy USP5-IN-1 | purchase USP5-IN-1 | USP5-IN-1 cost | order USP5-IN-1 | USP5-IN-1 chemical structure | USP5-IN-1 formula | USP5-IN-1 molecular weight
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