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ES9-17

Name: ES9-17
Brand: TargetMol
SKU: T64368
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64368Cas No. 55854-43-8

ES9-17, an analog of ES9 (endosidin9), is an inhibitor of clathrin-mediated endocytosis (CME). ES9-17 inhibits the uptake of FM4-64 and transferrin. ES9-17 inhibits root growth of Arabidopsis seedings.

ES9-17

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Purity: 99.93%

Catalog No. T64368Cas No. 55854-43-8

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$50	In Stock	In Stock
10 mg	$75	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$192	In Stock	In Stock
100 mg	$287	-	In Stock
200 mg	$431	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	ES9-17, an analog of ES9 (endosidin9), is an inhibitor of clathrin-mediated endocytosis (CME). ES9-17 inhibits the uptake of FM4-64 and transferrin. ES9-17 inhibits root growth of Arabidopsis seedings.
In vitro	ES9-17 (0-100 μM; 30 min) inhibits the absorption of the lipophilic styrene-based endocytosis tracer (FM4-64) with an EC50 of 13 μM, does not deplete ATP in Arabidopsis cells at 30 μM for 30 min, reduces the uptake of transferrin in HeLa cells at 30 μM for 30 min [1], targets CHC, regulates the inner membrane transport pathway, and does not cause cytoplasmic acidification [2].

Chemical Properties

Molecular Weight	318.21
Formula	C₁₀H₈BrNO₂S₂
Cas No.	55854-43-8
Smiles	BrC1=CC=C(S1)S(=O)(=O)NC1=CC=CC=C1
Relative Density.	1.727 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (392.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1426 mL	15.7129 mL	31.4258 mL	157.1289 mL
5 mM	0.6285 mL	3.1426 mL	6.2852 mL	31.4258 mL
10 mM	0.3143 mL	1.5713 mL	3.1426 mL	15.7129 mL
20 mM	0.1571 mL	0.7856 mL	1.5713 mL	7.8564 mL
50 mM	0.0629 mL	0.3143 mL	0.6285 mL	3.1426 mL
100 mM	0.0314 mL	0.1571 mL	0.3143 mL	1.5713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc