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Paquinimod

Catalog No. T7310 CAS 248282-01-1

Synonyms: ABR 25757

Paquinimod (ABR 25757) is a S100A9 inhibitor preventing S100A9 binding to TLR-4.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Paquinimod, CAS 248282-01-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
5 mg	In stock	$ 76.00
10 mg	In stock	$ 123.00
25 mg	In stock	$ 229.00
50 mg	In stock	$ 373.00
100 mg	In stock	$ 473.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 99.79%

Purity: 99.61%

Purity: 98.04%

Purity: 97.62%

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Description	Paquinimod (ABR 25757) is a S100A9 inhibitor preventing S100A9 binding to TLR-4.
In vivo	Prophylactic treatment of paquinimod reduces synovial activation, osteophyte formation and cartilage damage in experimental OA with high synovial activation (CIOA) and ameliorates pathological effects of S100A9 in OA synovium ex vivo[1].Treatment with paquinimod reduces skin fibrosis measured as reduction of skin thickness and decreased number of myofibroblasts and total hydroxyproline content. The effect on fibrosis was associated with a polarization of macrophages in the skin from a pro-fibrotic M2 to a M1 phenotype. Paquinimod treatment also resulted in a reduced TGFβ-response in the skin and an abrogation of the increased auto-antibody production in this SSc model[1].
Animal Research	Two OA mouse models differing in level of synovial activation were treated prophylactic with paquinimod. Synovial thickening, osteophyte size and cartilage damage were measured histologically, using an arbitrary score, adapted Pritzker OARSI score or imaging software, respectively. Human OA synovia were stimulated with S100A9, with or without paquinimod[1].Seven weeks old female B6.Cg-Fbn1(Tsk)/J (Tsk-1) mice were treated with vehicle or paquinimod at the dose of 5 or 25mg/kg/day in the drinking water for 8 weeks. The effect of paquinimod on the level of skin fibrosis and on different subpopulations within the myeloid cell compartment in skin biopsies were evaluated by using histology, immunohistochemisty, a hydroxyproline assay and real-time PCR. Furthermore, the level of IgG in serum from treated animals was also analysed. The statistical analyses were performed using Mann-Whitney nonparametric two tailed rank test[1].

Synonyms	ABR 25757
Molecular Weight	350.41
Formula	C21H22N2O3
CAS No.	248282-01-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

5% DMSO+95% Saline: 6.25 mg/mL (17.84 mM, suspension)

DMSO: 50 mg/mL (142.69 mM)

References and Literature

1. Schelbergen R F , Geven E J , Van d B M H J , et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis[J]. Annals of the Rheumatic Diseases, 2015:annrheumdis-2014-206517. 2. StenstrM M , Nyhlén, Helén Carlsson, T?Rngren M , et al. Paquinimod reduces skin fibrosis in tight skin 1 mice, an experimental model of systemic sclerosis[J]. Journal of Dermatological Science, 2016:S0923181116300615. 3. Guo Q, Zhao Y, Li J, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19[J]. Cell Host & Microbe . 2020

Citations

1. Guo Q, Zhao Y, Li J, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host & Microbe. 2020 2. Jiang H, Zhao Y, Su M, et al.A proteome-wide screen identifies the calcium binding proteins, S100A8/S100A9, as clinically relevant therapeutic targets in aortic dissection.Pharmacological Research.2023: 107029.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Clinical Compound Library ReFRAME Related Library NO PAINS Compound Library Bioactive Compound Library Human Metabolite Library Bioactive Compounds Library Max Anti-Viral Compound Library

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Keywords

Paquinimod 248282-01-1 Others Inhibitor inhibit ABR25757 ABR-25757 ABR 25757 inhibitor

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