keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 50.00 | |
5 mg | Inquiry | $ 143.00 | |
10 mg | Inquiry | $ 235.00 | |
25 mg | Inquiry | $ 329.00 |
Description | Alpha-1 antitrypsin (A1AT) is known as a serum trypsin inhibitor and is a protease inhibitor belonging to the serpin superfamily. Alpha-1 antitrypsin is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits a number of glycoforms. |
In vitro | A1AT is a major inhibitor of human serine proteases in serum, is produced mainly by the liver, but also by extrahepatic cells, including neutrophils and certain cancer cells. AAT is an acute-phase protein and its concentration rises up to 3–4-fold above normal during acute inflammation. Several types of cancer, including non-small cell lung adenocarcinoma, have been associated with increased serum levels of AAT [1][2][3]. |
In vivo | Moreover, not only the native, the inhibitory form of AAT but also conformationally modified, non-inhibitory forms are suggested to play a role in modulating tumor growth and invasiveness. For example, Kataoka and co-workers have shown that the C-terminal fragment of AAT can enhance the growth and invasiveness of human pancreas adenocarcinoma cells, in vivo [5]. |
Molecular Weight | 1804.01 |
Formula | C79H130N22O26 |
CAS No. | TP2217 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: > 45.1 mg/mL, Heating is recommended.
You can also refer to dose conversion for different animals. More
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