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Lipoxamycin hemisulfate

Name: Lipoxamycin hemisulfate
Brand: TargetMol
SKU: T26308
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26308Cas No. 11075-87-9

Alias U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), Lipoxamycin

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

Lipoxamycin hemisulfate

😃Good

Purity: 99.93%

Catalog No. T26308Alias U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), LipoxamycinCas No. 11075-87-9

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	In Stock	In Stock
2 mg	$72	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$762	In Stock	In Stock
100 mg	$1,290	-	In Stock
200 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.93%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.
In vitro	Lipoxamycin hemisulfate shows antifungal activity against a panel of human pathogenic fungi with better potency against some of the Candida species (MIC = 0.25-16 µg/mL)[1].
In vivo	In Chinese hamster ovary cell mutant, Lipoxamycin hemisulfate is highly toxic in mice when applied subeutaneously or topically[1].
Synonyms	U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), Lipoxamycin

Chemical Properties

Molecular Weight	843.08
Formula	C₃₈H₇₄N₄O₁₄S
Cas No.	11075-87-9
Smiles	CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.OS(=O)(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36 mg/mL (42.7 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (3.91 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1861 mL	5.9306 mL	11.8613 mL	59.3064 mL
5 mM	0.2372 mL	1.1861 mL	2.3723 mL	11.8613 mL
10 mM	0.1186 mL	0.5931 mL	1.1861 mL	5.9306 mL
20 mM	0.0593 mL	0.2965 mL	0.5931 mL	2.9653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc