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Lipoxamycin hemisulfate

Name: Lipoxamycin hemisulfate
Brand: TargetMol
SKU: T26308
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26308Cas No. 11075-87-9

Alias U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), Lipoxamycin

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

Lipoxamycin hemisulfate

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Purity: 99.93%

Catalog No. T26308Alias U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), LipoxamycinCas No. 11075-87-9

Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	In Stock	In Stock
2 mg	$72	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$446	In Stock	In Stock
50 mg	$762	In Stock	In Stock
100 mg	$1,290	-	In Stock
200 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.93%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lipoxamycin hemisulfate (Lipoxamycin) is an inhibitor of serine palmitoyltransferase (IC50 = 21 nM) with antifungal activity.
In vitro	Lipoxamycin hemisulfate shows antifungal activity against a panel of human pathogenic fungi with better potency against some of the Candida species (MIC = 0.25-16 µg/mL)[1].
In vivo	In Chinese hamster ovary cell mutant, Lipoxamycin hemisulfate is highly toxic in mice when applied subeutaneously or topically[1].
Synonyms	U-26146D, U26146D, U 26146D, Lipoxamycin, sulfate (2:1), Lipoxamycin

Chemical Properties

Molecular Weight	843.08
Formula	C₃₈H₇₄N₄O₁₄S
Cas No.	11075-87-9
Smiles	CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.CC(C)CCCC(=O)CCCCCCC(=O)CCN(C(=O)[C@H](CO)N)O.OS(=O)(=O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.3 mg/mL (26.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.3 mg/mL (3.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1861 mL	5.9306 mL	11.8613 mL	59.3064 mL
5 mM	0.2372 mL	1.1861 mL	2.3723 mL	11.8613 mL
10 mM	0.1186 mL	0.5931 mL	1.1861 mL	5.9306 mL
20 mM	0.0593 mL	0.2965 mL	0.5931 mL	2.9653 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc