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GR 103691

🥰Excellent
Catalog No. T11463Cas No. 162408-66-4

GR 103691, a potent and selective dopamine D3 receptor antagonist (Ki: 0.4 nM), exhibits more than 100-fold selectivity for human dopamine D3 receptors over human D4 and D1 sites.

GR 103691

GR 103691

🥰Excellent
Purity: 99.29%
Catalog No. T11463Cas No. 162408-66-4
GR 103691, a potent and selective dopamine D3 receptor antagonist (Ki: 0.4 nM), exhibits more than 100-fold selectivity for human dopamine D3 receptors over human D4 and D1 sites.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$35In StockIn Stock
5 mg$56In StockIn Stock
10 mg$98In StockIn Stock
25 mg$197In StockIn Stock
50 mg$322In StockIn Stock
100 mg$513In StockIn Stock
200 mg$728In StockIn Stock
1 mL x 10 mM (in DMSO)$60In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.29%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
GR 103691, a potent and selective dopamine D3 receptor antagonist (Ki: 0.4 nM), exhibits more than 100-fold selectivity for human dopamine D3 receptors over human D4 and D1 sites.
Targets&IC50
D3:ki:0.4 nM
In vitro
GR 103691 shows a marked affinity for α-1 adrenoceptors (Ki: 12.6 nM) and serotonin1A (5-HT1A) receptors (Ki: 5.8 nM).
Chemical Properties
Molecular Weight485.62
FormulaC30H35N3O3
Cas No.162408-66-4
SmilesCOc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)-c2ccc(cc2)C(C)=O)CC1
Relative Density.1.132 g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 4.86 mg/mL (10.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0592 mL10.2961 mL20.5922 mL102.9612 mL
5 mM0.4118 mL2.0592 mL4.1184 mL20.5922 mL
10 mM0.2059 mL1.0296 mL2.0592 mL10.2961 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

InhibitorinhibitHuman dopamine D3 receptorGR-103691GR103691GR 103691DopamineReceptorDopamine ReceptorDopamineD3
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