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UNC10112785
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Catalog No. T68758Cas No. 748142-06-5
Alias UNC-10112785, UNC 10112785
UNC10112785 is a novel and potent inhibitor of CDK8, CDK19, and CDK9 with IC50 values of 1.05 nM, 2.67 nM, and 19.9 nM, respectively, inducing MYC protein loss via both transcriptional and post-translational mechanisms. UNC10112785 suppresses pancreatic ductal adenocarcinoma (PDAC) growth under both anchorage-dependent and anchorage-independent conditions, causing substantial MYC depletion in two-dimensional and three-dimensional cell culture models.
UNC10112785
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Purity: 98.12%
Catalog No. T68758Alias UNC-10112785, UNC 10112785Cas No. 748142-06-5
UNC10112785 is a novel and potent inhibitor of CDK8, CDK19, and CDK9 with IC50 values of 1.05 nM, 2.67 nM, and 19.9 nM, respectively, inducing MYC protein loss via both transcriptional and post-translational mechanisms. UNC10112785 suppresses pancreatic ductal adenocarcinoma (PDAC) growth under both anchorage-dependent and anchorage-independent conditions, causing substantial MYC depletion in two-dimensional and three-dimensional cell culture models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.12%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | UNC10112785 is a novel and potent inhibitor of CDK8, CDK19, and CDK9 with IC50 values of 1.05 nM, 2.67 nM, and 19.9 nM, respectively, inducing MYC protein loss via both transcriptional and post-translational mechanisms. UNC10112785 suppresses pancreatic ductal adenocarcinoma (PDAC) growth under both anchorage-dependent and anchorage-independent conditions, causing substantial MYC depletion in two-dimensional and three-dimensional cell culture models. |
| Targets&IC50 | CDK19:~2-10 nM, CDK8:~1-5 nM |
| In vitro | In HCT116 colon cancer cells, UNC10112785 has antiproliferative activity with IC50 values between 5-50 nM [1]. |
| In vivo | In preclinical xenograft models of colorectal and pancreatic cancer, systemic administration of this class of inhibitors (UNC10112785) leads to tumor growth delay [2]. |
| Synonyms | UNC-10112785, UNC 10112785 |
| Molecular Weight | 330.39 |
| Formula | C19H18N6 |
| Cas No. | 748142-06-5 |
| Smiles | N1=CC=C(N=C1NC2=CC=C(C=C2)C(C)C)C=3C=NN4N=CC=CC34 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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