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B7/CD28 interaction inhibitor 1

🥰Excellent
Catalog No. T3189Cas No. 635324-72-0
Alias CTLA-4 inhibitor

B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.

B7/CD28 interaction inhibitor 1

B7/CD28 interaction inhibitor 1

🥰Excellent
Purity: 99.63%
Catalog No. T3189Alias CTLA-4 inhibitorCas No. 635324-72-0
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$77In StockIn Stock
2 mg$115In StockIn Stock
5 mg$193In StockIn Stock
10 mg$313In StockIn Stock
25 mg$578In StockIn Stock
50 mg$828In StockIn Stock
100 mg$1,090In StockIn Stock
1 mL x 10 mM (in DMSO)$213In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.63%
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Product Introduction

Bioactivity
Description
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) is a potent CTLA-4 inhibitor.
Targets&IC50
B7.1-CD28 interaction:50 nM (IC50)
SynonymsCTLA-4 inhibitor
Chemical Properties
Molecular Weight427.35
FormulaC21H13F4N5O
Cas No.635324-72-0
SmilesCn1ncc2c1nc(-c1cccc(c1)C(F)(F)F)c1c2[nH]n(-c2ccc(F)cc2)c1=O
Relative Density.1.54 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 85 mg/mL (198.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3400 mL11.7000 mL23.4000 mL117.0001 mL
5 mM0.4680 mL2.3400 mL4.6800 mL23.4000 mL
10 mM0.2340 mL1.1700 mL2.3400 mL11.7000 mL
20 mM0.1170 mL0.5850 mL1.1700 mL5.8500 mL
50 mM0.0468 mL0.2340 mL0.4680 mL2.3400 mL
100 mM0.0234 mL0.1170 mL0.2340 mL1.1700 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

T-cellresponsesInhibitorinhibitimmunosuppressionCTLA-4CD28B-7/CD28 interaction inhibitor 1B7/CD28 interaction inhibitor 1B7.1antibodies
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