Shopping Cart

Your shopping cart is currently empty

Wy 49051

Name: Wy 49051
Brand: TargetMol
SKU: T13352
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13352Cas No. 113418-56-7

Alias Wy-49051

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).

Wy 49051

🥰Excellent

Purity: 99.89%

Catalog No. T13352Alias Wy-49051Cas No. 113418-56-7

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	-	In Stock
5 mg	$209	-	In Stock
10 mg	$303	-	In Stock
25 mg	$475	-	In Stock
50 mg	$638	-	In Stock
100 mg	$826	-	In Stock
200 mg	$1,100	-	In Stock
1 mL x 10 mM (in DMSO)	$277	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Targets&IC50	H1 receptor:44 nM
In vitro	Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM[1].
In vivo	Wy 49051 demonstrates efficacy in counteracting histamine-induced lethality in guinea pigs, with effective doses (ED50) of 1.91 mg/kg orally (po), 0.70 mg/kg intraperitoneally (ip), and 0.01 mg/kg intravenously (iv). Additionally, the compound maintains its oral efficacy without any reduction for up to 18 hours posttreatment[1].
Synonyms	Wy-49051

Chemical Properties

Molecular Weight	487.59
Formula	C₂₈H₃₃N₅O₃
Cas No.	113418-56-7
Smiles	C(CCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)N4C5=C(N(C)C(=O)N(C)C5=O)N=C4
Relative Density.	1.25 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (92.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0509 mL	10.2545 mL	20.5090 mL	102.5452 mL
5 mM	0.4102 mL	2.0509 mL	4.1018 mL	20.5090 mL
10 mM	0.2051 mL	1.0255 mL	2.0509 mL	10.2545 mL
20 mM	0.1025 mL	0.5127 mL	1.0255 mL	5.1273 mL
50 mM	0.0410 mL	0.2051 mL	0.4102 mL	2.0509 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc