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Wy 49051

Name: Wy 49051
Brand: TargetMol
SKU: T13352
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13352Cas No. 113418-56-7

Alias Wy-49051

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).

Wy 49051

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Purity: 99.89%

Catalog No. T13352Alias Wy-49051Cas No. 113418-56-7

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	-	In Stock
5 mg	$209	-	In Stock
10 mg	$303	-	In Stock
25 mg	$475	-	In Stock
50 mg	$638	-	In Stock
100 mg	$826	-	In Stock
200 mg	$1,100	-	In Stock
1 mL x 10 mM (in DMSO)	$230	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Targets&IC50	H1 receptor:44 nM
In vitro	Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM[1].
In vivo	Wy 49051 demonstrates efficacy in counteracting histamine-induced lethality in guinea pigs, with effective doses (ED50) of 1.91 mg/kg orally (po), 0.70 mg/kg intraperitoneally (ip), and 0.01 mg/kg intravenously (iv). Additionally, the compound maintains its oral efficacy without any reduction for up to 18 hours posttreatment[1].
Synonyms	Wy-49051

Chemical Properties

Molecular Weight	487.59
Formula	C₂₈H₃₃N₅O₃
Cas No.	113418-56-7
Smiles	C(CCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)N4C5=C(N(C)C(=O)N(C)C5=O)N=C4
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (92.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0509 mL	10.2545 mL	20.5090 mL	102.5452 mL
5 mM	0.4102 mL	2.0509 mL	4.1018 mL	20.5090 mL
10 mM	0.2051 mL	1.0255 mL	2.0509 mL	10.2545 mL
20 mM	0.1025 mL	0.5127 mL	1.0255 mL	5.1273 mL
50 mM	0.0410 mL	0.2051 mL	0.4102 mL	2.0509 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc