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SB 243213
🥰Excellent
Catalog No. T37816Cas No. 200940-22-3
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
SB 243213
🥰Excellent
Purity: 99.86%
Catalog No. T37816Cas No. 200940-22-3
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 5 mg | $73 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $289 | In Stock | |
| 50 mg | $538 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.86%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders. |
| Targets&IC50 | 5-HT1E Receptor (human):<5.4 (pKi), 5-HT7 receptor (human):5.64 (pKi), 5-HT1F Receptor (human):5.35 (pKi), 5-HT1A receptor (human):<5.3 (pKi), 5-HT6 receptor (human):6.5 (pKi), 5-HT2C receptor (human):9.37 (pKi), 5-HT1B receptor (human):5.5 (pKi), 5-HT2B receptor (human):7.2 (pKi), 5-HT2A receptor (human):7.01 (pKi), 5-HT1D receptor (human):6.32 (pKi) |
| In vitro | SB 243213 exhibits low affinity for cloned human 5-HT1D, 5-HT1A, 5-HT1B, 5-HT1E, 5-HT1F, and 5-HT7 receptors[1]. |
| In vivo | In experimentally naive male Sprague-Dawley rats weighing 220-300 g, SB 243213 (0.1, 0.3, 1, 3, 10 mg/kg; oral administration; 1 hour pre-test) dose-dependently and significantly increased the duration of social interaction in brightly lit conditions and in an unfamiliar test box, lasting for 15 minutes[1]. |
| Molecular Weight | 428.41 |
| Formula | C22H19F3N4O2 |
| Cas No. | 200940-22-3 |
| Smiles | Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1C(F)(F)F |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (233.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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