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Substance P (7-11) acetate
🥰Excellent
Catalog No. T7554L1
Alias Substance P (7-11) acetate (51165-05-0 free base)
Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.
Substance P (7-11) acetate
🥰Excellent
Purity: 99.567%
Catalog No. T7554L1Alias Substance P (7-11) acetate (51165-05-0 free base)
Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $41 | In Stock | |
| 5 mg | $66 | In Stock | |
| 10 mg | $116 | In Stock | |
| 25 mg | $197 | In Stock | |
| 50 mg | $296 | In Stock |
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Purity:99.567%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research. |
| In vitro | Substance P (7-11) acetate at concentrations greater than 1μM can promote the production of prostaglandin E₂ (PGE₂) and collagenase. Fluorescent dye Fura-2 detection revealed that the substance capable of increasing intracellular calcium concentration is Substance P (7-11), whereas intact SP, SP-(1-4), SP-(1-6), SP-(8-11) or SP-(9-11), as well as tachykinin family members neurokinin A (NKA) and neurokinin B (NKB), failed to induce the aforementioned intracellular calcium elevation effect. Additionally, the maximum change in intracellular calcium concentration induced by 10μM Substance P (7-11) was 140±30nM [1]. |
| Synonyms | Substance P (7-11) acetate (51165-05-0 free base) |
| Molecular Weight | 612.79 (free base) |
| Formula | C31H44N6O5S.xC2H4O2 |
| Smiles | N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O |
| Color | White |
| Appearance | Solid |
| Sequence | Phe-Phe-Gly-Leu-Met-NH2 |
| Sequence Short | FFGLM-NH2 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 1.5 mg/mL, when pH is adjusted to 2 with HCl. Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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