Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Substance P (7-11) acetate

Copy Product Info

😃Good

Catalog No. T7554L1

Alias Substance P (7-11) acetate (51165-05-0 free base)

Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.

Substance P (7-11) acetate

Copy Product Info

😃Good

Purity: 99.56%

Catalog No. T7554L1Alias Substance P (7-11) acetate (51165-05-0 free base)

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$41	-	In Stock
5 mg	$66	-	In Stock
10 mg	$116	-	In Stock
25 mg	$197	-	In Stock
50 mg	$296	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.56%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS

Product Introduction

Bioactivity

Description	Substance P (7-11) acetate is a specific fragment of the neuropeptide Substance P, acting as a neurotransmitter and neuromodulator in the central nervous system, with its endogenous receptor being neurokinin 1 (NK1R), making it useful for neurophysiological and pharmacological research.
In vitro	Substance P (7-11) acetate at concentrations greater than 1μM can promote the production of prostaglandin E₂ (PGE₂) and collagenase. Fluorescent dye Fura-2 detection revealed that the substance capable of increasing intracellular calcium concentration is Substance P (7-11), whereas intact SP, SP-(1-4), SP-(1-6), SP-(8-11) or SP-(9-11), as well as tachykinin family members neurokinin A (NKA) and neurokinin B (NKB), failed to induce the aforementioned intracellular calcium elevation effect. Additionally, the maximum change in intracellular calcium concentration induced by 10μM Substance P (7-11) was 140±30nM [1].
Synonyms	Substance P (7-11) acetate (51165-05-0 free base)

Chemical Properties

Molecular Weight	612.79 (free base)
Formula	C₃₁H₄₄N₆O₅S.xC₂H₄O₂
Smiles	N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC2=CC=CC=C2)=O.CC(O)=O
Sequence	Phe-Phe-Gly-Leu-Met-NH2
Sequence Short	FFGLM

Storage & Solubility Information

Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O: 1.5 mg/mL, when pH is adjusted to 2 with HCl. Sonication is recommended.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc