Shopping Cart
- Remove All
Your shopping cart is currently empty
P2Y14R antagonist 3
😃Good
Catalog No. T205281
P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases.
P2Y14R antagonist 3
P2Y14R antagonist 3
😃Good
Catalog No. T205281
P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
Bulk & Custom
Questions
View MoreInhibitors Related to "P2Y14R antagonist 3"
cangrelor tetrasodium
T5036163706-36-3
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
- $39
Size
QTY
(±) Clopidogrel hydrogen sulfate
Plavix, Iscover, Clopidogrel hydrogen sulfate
T0182L2135046-48-9
(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in various conditions such as cerebrovascular disease, peripheral vascular disease, and coronary artery disease.
- $50
Size
QTY
Ticagrelor
AZD6140, AR-C 126532XX
T0179274693-27-5
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010, and by the US FDA on July 20, 2011. Its trade names are Brilinta (US), Brilique(EU) and Possia(EU).
- $30
Size
QTY
Diquafosol tetrasodium
Cited
INS365
T7423211427-08-6
Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film stability and visual function, as a topical treatment of dry eye disease.
- $39
Size
QTY
CitedClopidogrel hydrogen sulfate
SR-25990C, (S)-(+)-Clopidogrel hydrogen sulfate, (S)-(+)-Clopidogrel bisulfate
T0182L120202-66-6
Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets and platelet adhesion and aggregation.
- $30
Size
QTY
Regrelor disodium
Regrelor sodium, Regrelor, INS-50589, INS50589, INS 50589
T34280676251-22-2In house
Regrelor disodium (INS 50589) is a P2Y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, curbs cell proliferation, and reduces inflammation.
- $117
Size
QTY
Uridine 5′-diphosphoglucose disodium salt
Uridine 5'-diphosphoglucose disodium sal, UDP-α-D-Glucose sodium salt, UDP-Glucose sodium salt, UDPG sodium salt
T474328053-08-9
Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It is an agonist of the P2Y14 receptor (EC50 = 0.35 μM) and can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.
- $42
Size
QTY
Clopidogrel
SR-25990C, (S)-Clopidogrel
T0182113665-84-2
Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
- $41
Size
QTY
Prasugrel Hydrochloride
Prasugrel HCl, PCR 4099 (hydrochloride), LY 640315 Hydrochloride, Effient
T6952389574-19-0
Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients with acute coronary syndrome.
- $30
Size
QTY
PSB-16133 sodium
PSB-16133, PSB16133, PSB 16133
T284632089035-40-3In house
PSB-16133 sodium is a selective P2Y purine receptor variant antagonist with an IC of 233 nM.
- $293
Size
QTY
Uridine-5'-diphosphate disodium salt Cited
UDP disodium salt
T470627821-45-0
Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of inflammatory mediators, phagocytosis, and vasoconstriction. Uridine-5'-diphosphate disodium salt also acts as an antagonist of P2Y14.
- $32
Size
QTY
CitedPrasugrel
PCR 4099, LY640315, CS-747
T0230150322-43-3
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those undergoing PERCUTANEOUS CORONARY INTERVENTIONS.
- $35
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | P2Y14R antagonist 3 (compound A) is an orally active P2Y14R antagonist with an IC50 of 23.60 nM and a Kd of 7.26 μM. It mitigates lung injury in mice induced by Lipopolysaccharides (LPS) and can be utilized in the study of inflammatory diseases. |
| Targets&IC50 | P2Y14 Receptor:7.26 μM(Kd) |
| In vitro | P2Y14R antagonist 3 does not inhibit CYP1A2 and CYP2C9, but exhibits weak inhibitory activity against CYP2C19 and CYP3A4 with IC 50 values of 28.6 μM and 21.3 μM, respectively [1]. This compound shows no cardiotoxic side effects and demonstrates excellent biopharmaceutical stability, resisting degradation in simulated gastric and intestinal fluids. It also maintains high metabolic stability in human liver microsomes, categorizing it as a low-clearance compound [1]. |
| In vivo | The administration of P2Y14R antagonist 3 (2–6 mg/kg; oral administration; once daily for 7 consecutive days) mitigates the severity of lung injury in mice induced by LPS, leading to reduced immune cell infiltration and significantly lower levels of inflammatory factors IL-6, TNF-α, and IL-1β. |
| Molecular Weight | 487.51 |
| Formula | C26H25N5O5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Sci Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy P2Y14R antagonist 3 | purchase P2Y14R antagonist 3 | P2Y14R antagonist 3 cost | order P2Y14R antagonist 3 | P2Y14R antagonist 3 in vivo | P2Y14R antagonist 3 in vitro | P2Y14R antagonist 3 formula | P2Y14R antagonist 3 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.