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MCHR1 antagonist 2
🥰Excellent
Catalog No. T11966Cas No. 863115-70-2
MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.
MCHR1 antagonist 2
🥰Excellent
Purity: 98.29%
Catalog No. T11966Cas No. 863115-70-2
MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $38 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $107 | In Stock | |
| 25 mg | $233 | In Stock | |
| 50 mg | $371 | In Stock | |
| 100 mg | $596 | In Stock | |
| 200 mg | $788 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $77 | In Stock |
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Purity:98.29%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG. |
| Targets&IC50 | ERG (human):4.0 nM(IMR-32 cells), Ca2+ flux:196 ± 30 nM((IMR-32 cells)), MCH1R:65 nM |
| In vitro | MCHR1 antagonist 2 has inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively, in IMR-32 cells.MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. |
| Molecular Weight | 424.42 |
| Formula | C23H21FN2O5 |
| Cas No. | 863115-70-2 |
| Smiles | Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1 |
| Relative Density. | 1.31g/cm3 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (21.21 mM), when pH is adjusted to 6 with HCl. Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.36 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Potassium ChannelMelaninconcentratingHormoneReceptor(MCHR)MelaninconcentratingHormoneReceptorMelaninconcentrating Hormone Receptor (MCHR)Melanin-concentrating Hormone ReceptorMelanin concentrating hormone receptor 1melanin concentrating hormone receptor 1melaninMCHR-1 antagonist 2MCHR1 antagonist 2MCHR1 (GPR24)MCHRMCH1-RKcsAInhibitorinhibitIMR-32hormonehERG in IMR-32 cellshERGconcentrating
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