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Anti-LYVE1 Antibody (3Z624)
😃Good
Catalog No. TMAC-02440
Alias XLKD1, LYVE-1, Lymphatic vessel endothelial hyaluronic acid receptor 1, Hyaluronic acid receptor, HAR, Extracellular link domain-containing protein 1, CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1
Anti-LYVE1 Antibody (3Z624) is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Antibody (3Z624) can be used in WB,ICC/IF,IHC,FCM.
Anti-LYVE1 Antibody (3Z624)
Anti-LYVE1 Antibody (3Z624)
😃Good
Catalog No. TMAC-02440Alias XLKD1, LYVE-1, Lymphatic vessel endothelial hyaluronic acid receptor 1, Hyaluronic acid receptor, HAR, Extracellular link domain-containing protein 1, CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1
Anti-LYVE1 Antibody (3Z624) is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Antibody (3Z624) can be used in WB,ICC/IF,IHC,FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-LYVE1 Antibody (3Z624) is a Rabbit antibody targeting LYVE1. Anti-LYVE1 Antibody (3Z624) can be used in WB,ICC/IF,IHC,FCM. |
| Synonyms | XLKD1, LYVE-1, Lymphatic vessel endothelial hyaluronic acid receptor 1, Hyaluronic acid receptor, HAR, Extracellular link domain-containing protein 1, CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1 |
| Ig Type | IgG |
| Clone | 3Z624 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of LYVE1 on MCF-7 lysates using anti-LYVE1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-LYVE1 antibody. Counter stained with hematoxylin. 3. ICC staining LYVE1 in A431 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining LYVE1 in HUVEC cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. ICC staining LYVE1 in SW480 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. Flow cytometric analysis of HUVEC cells with LYVE1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1) is expressed on the cell surface as a protein that is reduced by glycosidase treatment. LYVE-1 is abundant in spleen, lymph node, heart, lung and fetal liver, and is less abundant in appendix, bone marrow, placenta, muscle and adult liver. Expression of LYVE-1 is largely restricted to endothelial cells lining lymphatic vessels and splenic sinusoidal endothelial cells. LYVE-1 binds to both soluble and immobilized hyaluronan (HA) with greater specificity than HCAM. Like HCAM, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike HCAM, the LYVE-1 molecule co-localizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE-1 is used as a marker to study tumor lymphangiogenesis, which is an important area of investigation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 35 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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