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PQR530

Name: PQR530
Brand: TargetMol
SKU: T16567
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16567Cas No. 1927857-61-1

Alias PQR-530

PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitumor activity.

PQR530

🥰Excellent

Purity: 99.5%

Catalog No. T16567Alias PQR-530Cas No. 1927857-61-1

Pack Size	Price	Availability
1 mg	$29	In Stock
5 mg	$68	In Stock
10 mg	$98	In Stock
25 mg	$197	In Stock
50 mg	$293	In Stock
100 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$75	In Stock

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Purity:99.5%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation with IC50 values of 0.07 μM. It also showing antitumor activity.
Targets&IC50	PI3Kβ:6.1 nM (Kd), PI3KC2β:100 nM (Kd), PI3Kα:0.84 nM (Kd), mTOR:0.33 nM (Kd), PI3Kγ:10 nM (Kd), PI3Kδ:11 nM (Kd)
In vitro	PQR-530 inhibits all PI3K isoforms and mTOR complexes C1/2 potently and selectively. PQR-530 inhibits protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phosphorylation (IC50: 0.07 μM in A2058 melanoma cells). PQR-530 displays inhibitory activity against the growth of 44 cancer cell lines (mean GI50: 426 nM)[1].
Synonyms	PQR-530

Chemical Properties

Molecular Weight	407.42
Formula	C₁₈H₂₃F₂N₇O₂
Cas No.	1927857-61-1
Smiles	C[C@H]1COCCN1c1nc(nc(n1)-c1cnc(N)cc1C(F)F)N1CCOCC1
Relative Density.	1.338 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (61.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4545 mL	12.2723 mL	24.5447 mL	122.7235 mL
5 mM	0.4909 mL	2.4545 mL	4.9089 mL	24.5447 mL
10 mM	0.2454 mL	1.2272 mL	2.4545 mL	12.2723 mL
20 mM	0.1227 mL	0.6136 mL	1.2272 mL	6.1362 mL
50 mM	0.0491 mL	0.2454 mL	0.4909 mL	2.4545 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc