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(3S)-GSK-F1
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Catalog No. T67837Cas No. 1384097-27-1
Alias PI4KA inhibitor-F1
(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.
(3S)-GSK-F1
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Purity: 99.04%
Catalog No. T67837Alias PI4KA inhibitor-F1Cas No. 1384097-27-1
(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $67 | In Stock | In Stock | |
| 5 mg | $143 | In Stock | In Stock | |
| 10 mg | $233 | In Stock | In Stock | |
| 25 mg | $413 | In Stock | In Stock | |
| 50 mg | $592 | In Stock | In Stock | |
| 100 mg | $930 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $202 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.04%
Appearance:Solid
Color:Yellow
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Product Introduction
(3S)-GSK-F1 AI Summary
(3S)-GSK-F1 exhibits diverse bioactivities, including notable antiviral activity against various genotypes of the Hepatitis C virus with IC50 values from 2.512 nM to 125.89 nM. It demonstrates inhibitory effects on PI3K and PI4K isoforms, with varying IC50 values and selectivity ratios for different targets, such as PI3K isoforms and PI4K-alpha. In toxicity studies, the compound shows a maximum tolerated dose of 50.0 mg kg^-1 in mice after 14 days. It has been tested in Sprague-Dawley rats, where it demonstrates dose-normalized AUC values at different doses and routes of administration. The oral bioavailability in rats ranges from greater than 100.0% to 98.0%, and the compound displays different pharmacokinetic parameters, including Tmax, Cmax, Vdss, CL, and T1/2..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3. |
| Targets&IC50 | PI3Kδ:5.6 (pIC50), PI3Kβ:5.1 (pIC50), PI4KIIIβ:6.0 (pIC50), PI3Kα:5.6 (pIC50), PI4KIIIα:8.3 (pIC50) |
| Synonyms | PI4KA inhibitor-F1 |
| Molecular Weight | 603.52 |
| Formula | C27H18F5N5O4S |
| Cas No. | 1384097-27-1 |
| Smiles | O=C1N(C(N)=NC=2C1=CC(=CC2)C=3C=C(S(NC4=C(F)C=C(F)C=C4)(=O)=O)C(OC)=NC3)C5=C(C(F)(F)F)C=CC=C5 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (19.88 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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