Beta Klotho Protein, Mouse, Recombinant (His)

Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 511.00
500 μg	5 days	$ 2,040.00
1 mg	5 days	$ 3,410.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 511.00

500 μg

5 days

$ 2,040.00

1 mg

5 days

$ 3,410.00

Description

Species	Mouse
Expression System	HEK293
Tag	C-His
Accession Number	Q99N32-1
Synonyms	Klotho beta, β-klotho, MGC142213, βKlotho, β Klotho, KLB, beta-klotho, klotho beta like, BKL, klotho β like, betaKlotho, Klotho β
Construction	Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Phe53-Pro994.[Accession \|Q99N32-1]
Protein Purity	> 90% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Molecular Weight	The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS (pH 7.4).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.