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PDIA1-IN-1
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Catalog No. T212059
PDIA1-IN-1 is an inhibitor of protein disulfide isomerase 1 (PDIA1). It effectively hinders the assembly and activity of the NLRP3 inflammasome, with an IC50 value of 1 μM. Additionally, PDIA1-IN-1 can reduce the secretion of IL-1β and is applicable in research related to inflammatory and neurological diseases.
PDIA1-IN-1
PDIA1-IN-1
😃Good
Catalog No. T212059
PDIA1-IN-1 is an inhibitor of protein disulfide isomerase 1 (PDIA1). It effectively hinders the assembly and activity of the NLRP3 inflammasome, with an IC50 value of 1 μM. Additionally, PDIA1-IN-1 can reduce the secretion of IL-1β and is applicable in research related to inflammatory and neurological diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PDIA1-IN-1 is an inhibitor of protein disulfide isomerase 1 (PDIA1). It effectively hinders the assembly and activity of the NLRP3 inflammasome, with an IC50 value of 1 μM. Additionally, PDIA1-IN-1 can reduce the secretion of IL-1β and is applicable in research related to inflammatory and neurological diseases. |
| In vitro | PDIA1-IN-1 (Compound P11) inhibits the formation of ASC-GFP specks in lipopolysaccharide-pretreated THP1 monocytes with an IC50 of 890 nM. In a dose-dependent manner, PDIA1-IN-1 (1.25-2.5 μM, 2 h) binds to PDIA1 in these cells. It reduces IL-1β secretion in LPS-pretreated THP1 monocytes at concentrations of 5-10 μM for 1-16 hours. Additionally, 1 μM of PDIA1-IN-1 for 2 hours can restore cell viability, whereas 10 μM for 1 hour decreases cell viability in LPS-pretreated THP1 monocytes. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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