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GAD65 (524-543) acetate

Catalog No. TP4031 Copy Product Info
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GAD65 (524-543) acetate is a bioactive peptide, representing the amino acid sequence spanning the 524th to 543rd residues of glutamic acid decarboxylase 65 (GAD65). This compound is one of the initial segments found to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. It serves as a specific stimulator, potentially exhibiting low affinity for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate can increase the susceptibility of NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.

GAD65 (524-543) acetate

Copy Product Info
🥰Excellent
Catalog No. TP4031

GAD65 (524-543) acetate is a bioactive peptide, representing the amino acid sequence spanning the 524th to 543rd residues of glutamic acid decarboxylase 65 (GAD65). This compound is one of the initial segments found to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. It serves as a specific stimulator, potentially exhibiting low affinity for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate can increase the susceptibility of NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.

GAD65
(524-543) acetate
Other Forms of GAD65 (524-543) acetate:
GAD65 (524-543)T82354152468-44-5
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Product Introduction

Bioactivity
Description
GAD65 (524-543) acetate is a bioactive peptide, representing the amino acid sequence spanning the 524th to 543rd residues of glutamic acid decarboxylase 65 (GAD65). This compound is one of the initial segments found to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. It serves as a specific stimulator, potentially exhibiting low affinity for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate can increase the susceptibility of NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells.
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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