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Avermectin B1a

Name: Avermectin B1a
Brand: TargetMol
SKU: T7605
Rating: 4.5 (1 reviews)

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Catalog No. T7605Cas No. 65195-55-3

Alias Avamectin B1a, Abamectin B1a

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

Avermectin B1a

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Catalog No. T7605Alias Avamectin B1a, Abamectin B1aCas No. 65195-55-3

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$40	Inquiry	Inquiry
50 mg	$56	Inquiry	Inquiry
100 mg	$73	Inquiry	Inquiry
500 mg	$173	Inquiry	Inquiry
1 g	$256	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .
In vitro	The binding of the glycine receptor antagonist, strychnine, to both membranes and solubilized receptor from rat spinal cord, was inhibited by avermectin B1a with Ki values of 1.3 microM and 3.6 microM, and Hill coefficients of 0.46 and 0.62, respectively[1].
Synonyms	Avamectin B1a, Abamectin B1a

Chemical Properties

Molecular Weight	873.08
Formula	C₄₈H₇₂O₁₄
Cas No.	65195-55-3
Smiles	CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
Relative Density.	1.24 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (292.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1454 mL	5.7269 mL	11.4537 mL	57.2685 mL
5 mM	0.2291 mL	1.1454 mL	2.2907 mL	11.4537 mL
10 mM	0.1145 mL	0.5727 mL	1.1454 mL	5.7269 mL
20 mM	0.0573 mL	0.2863 mL	0.5727 mL	2.8634 mL
50 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1454 mL
100 mM	0.0115 mL	0.0573 mL	0.1145 mL	0.5727 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc