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ICI 89406

Name: ICI 89406
Brand: TargetMol
SKU: T22852
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22852Cas No. 53671-71-9

Alias 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea

ICI 89406 (1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea) is a β-adrenergic antagonist.

ICI 89406

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Purity: 99.92%

Catalog No. T22852Alias 1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylureaCas No. 53671-71-9

ICI 89406 (1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea) is a β-adrenergic antagonist.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$212	In Stock	In Stock
25 mg	$398	In Stock	In Stock
50 mg	$583	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$156	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

ICI 89406 AI Summary

ICI 89406 exhibits a broad spectrum of bioactivities, demonstrating notable antiviral, enzymatic, and cellular effects. It shows antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in both Caco-2 and VERO-6 cells, with inhibition rates of -4.03% and -0.22% at a concentration of 10 µM after 48 hours, respectively. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 30.65% at 20 µM. In enzyme assays, ICI 89406 inhibits human HDAC6 by 21.84% using a commercial peptide and 5.33% with a custom peptide substrate. Its impact on protein thermal stability varies, causing both stabilization and destabilization across different domains. The compound also shows complexity in GPCR beta-arrestin recruitment assays, affecting targets such as GPR119, APLNR, ADGRF1, ADRB2, FFAR4, GPR35, C5AR1, and S1PR1 with both inhibitory and stimulatory actions. Moreover, it displays cell-type dependent bioactivity in viability assays, promoting moderate growth in HEK293T cells but not significantly affecting U2OS cells or human fibroblasts. These diverse activities underscore the potential of ICI 89406 for further research across various biological pathways and disease models..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	ICI 89406 (1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea) is a β-adrenergic antagonist.
Synonyms	1-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-3-phenylurea

Chemical Properties

Molecular Weight	354.4
Formula	C₁₉H₂₂N₄O₃
Cas No.	53671-71-9
Smiles	OC(CNCCNC(=O)Nc1ccccc1)COc1ccccc1C#N
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 250 mg/mL (705.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8217 mL	14.1084 mL	28.2167 mL	141.0835 mL
5 mM	0.5643 mL	2.8217 mL	5.6433 mL	28.2167 mL
10 mM	0.2822 mL	1.4108 mL	2.8217 mL	14.1084 mL
20 mM	0.1411 mL	0.7054 mL	1.4108 mL	7.0542 mL
50 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8217 mL
100 mM	0.0282 mL	0.1411 mL	0.2822 mL	1.4108 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc