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HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His)
(Synonyms: TKR1, NGL, NEU, MLN19, MLN 19, HERV-W-ENV, HERVWENV, HERVW, HERV-7q, HERV7Q, HER-2/neu, HER-2, HER2, ERVWE1, erb-b2 receptor tyrosine kinase 2, ENVW, ENV, EGFR2, CD340) Copy Product InfoSynonyms: TKR1, NGL, NEU, MLN19, MLN 19, HERV-W-ENV, HERVWENV, HERVW, HERV-7q, HERV7Q, HER-2/neu, HER-2, HER2, ERVWE1, erb-b2 receptor tyrosine kinase 2, ENVW, ENV, EGFR2, CD340
Catalog No. TMPY-04684 Copy Product Info
HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P04626-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $47 | - | In Stock | |
| 10 µg | $74 | - | In Stock | |
| 20 µg | $118 | - | In Stock | |
| 50 µg | $228 | - | In Stock | |
| 100 µg | $366 | 7-10 days | 7-10 days | |
| 200 µg | $583 | 7-10 days | 7-10 days | |
| 500 µg | $1,180 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 99.6%; SEC-HPLC: 92.4%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.9 kDa and the accession number is P04626-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P04626-1 |
| Construction | A DNA sequence encoding the human ERBB2 (NP_004439.2) (Met1-Cys195) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Thr 23 |
| Protein Purity | ≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.  , |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | TKR1, NGL, NEU, MLN19, MLN 19, HERV-W-ENV, HERVWENV, HERVW, HERV-7q, HERV7Q, HER-2/neu, HER-2, HER2, ERVWE1, erb-b2 receptor tyrosine kinase 2, ENVW, ENV, EGFR2, CD340 |
| Research Background | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 20.9 kDa (predicted); 32 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) chemical structure | HER2/ERBB2 Protein, Human, Recombinant (aa 1-195, His) molecular weight
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