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SKF-86002
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Catalog No. T2367Cas No. 72873-74-6
Alias SKF86002
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
SKF-86002
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Purity: 99.85%
Catalog No. T2367Alias SKF86002Cas No. 72873-74-6
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $32 | - | In Stock | |
| 10 mg | $54 | - | In Stock | |
| 25 mg | $100 | - | In Stock | |
| 50 mg | $148 | - | In Stock | |
| 100 mg | $219 | - | In Stock | |
| 200 mg | $310 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.85%
Color:Yellow to Black
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Product Introduction
SKF-86002 AI Summary
SKF-86002 demonstrates significant inhibitory activity against several targets, including p38 alpha mitogen-activated protein kinase (MAPK) with an IC50 value of 400.0 nM, and in other bioassays with various IC50 values. It shows efficacy in in vivo models, such as adjuvant-induced arthritis in rats, significantly reducing inflammation at a dose of 50 mg/kg when administered orally. Additionally, it stimulates the right hind paw in a cutaneous oxazolone-induced contact sensitivity mouse model at a dose of 25 mg/kg. In human whole blood and peripheral blood mononuclear cells, SKF-86002 inhibits TNF-alpha and IL1-beta release with IC50 values ranging from 520.0 nM to 27000.0 nM. Furthermore, it inhibits other enzymes and pathways, including Prostaglandin H2 synthase 1 (PGHS-1) with an IC50 of 5400.0 nM and 5-lipoxygenase in rat RBL-1 cells with an IC50 of 10000.0 nM. It also inhibits the CSBP kinase in human THP-1 cells, Yes1 kinase, Marburg virus entry, and shows some activity against O. lienalis microfilariae. Despite its wide range of bioactivities, the compound displays low cytotoxicity against Rhesus Monkey LLCMK2 cells and has marginal activity against HDAC6 enzyme. Overall, SKF-86002 appears to have promising anti-inflammatory properties with potential therapeutic applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM). |
| Targets&IC50 | IL-1:1 μM, TNF-α:1 μM, p38 MAPk:0.5-1 μM |
| Synonyms | SKF86002 |
| Molecular Weight | 297.35 |
| Formula | C16H12FN3S |
| Cas No. | 72873-74-6 |
| Smiles | Fc1ccc(cc1)-c1nc2SCCn2c1-c1ccncc1 |
| Relative Density. | 1.39 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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