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Sparstolonin B

Catalog No. T38261 CAS 1259330-61-4

Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2].

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Sparstolonin B, CAS 1259330-61-4

Pack Size	Availability	Price/USD
2 mg	5 days	$ 97.00
5 mg	5 days	$ 197.00
25 mg	6-8 weeks	$ 626.00
50 mg	6-8 weeks	$ 814.00
100 mg	6-8 weeks	$ 1,210.00
1 mL * 10 mM (in DMSO)	5 days	$ 189.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2].
In vitro	Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells
In vivo	Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice[1]. Animal Model: 5-6-week-old male C57Bl/6 mice (body weight 18-20 g)[1]

Molecular Weight	268.22
Formula	C15H8O5
CAS No.	1259330-61-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Liang Q, et al. Characterization of sparstolonin B, a Chinese herb-derived compound, as a selective Toll-like receptor antagonist with potent anti-inflammatory properties. J Biol Chem. 2011;286(30):26470-26479. 2. Deng X, et al. The Chinese herb-derived Sparstolonin B suppresses HIV-1 transcription. Virol J. 2015;12:108. Published 2015 Jul 25. 3. Kumar A, et al. Sparstolonin B, a novel plant derived compound, arrests cell cycle and induces apoptosis in N-myc amplified and N-myc nonamplified neuroblastoma cells [published correction appears in PLoS One. 2016;11(7):e0159082]. PLoS One. 2014;9(5):e96343. Published 2014 May 1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sparstolonin B 1259330-61-4 inhibitor inhibit

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