ALK-1 Protein, Rat, Recombinant (His & hFc)

Name: ALK-1 Protein, Rat, Recombinant (His & hFc)
Brand: TargetMol
SKU: TMPY-00757
Rating: 4.5 (1 reviews)

(Synonyms: ACVRL1, activin A receptor type II-like 1) Copy Product Info

Synonyms: ACVRL1, activin A receptor type II-like 1

Catalog No. TMPY-00757 Copy Product Info

ALK-1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.7 kDa and the accession number is A6KCN1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$59	7-10 days	7-10 days
10 µg	$95	7-10 days	7-10 days
20 µg	$155	7-10 days	7-10 days
50 µg	$296	7-10 days	7-10 days
100 µg	$497	7-10 days	7-10 days
200 µg	$987	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 40-200 ng/mL in the presence of 2 ng/mL of recombinant human BMP9.
Description	ALK-1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 38.7 kDa and the accession number is A6KCN1.
Species	Rat
Expression System	HEK293 Cells
Tag	His, hFc
Accession Number	A6KCN1
Construction	A synthetic DNA sequence encoding the rat ACVRL1 (NP_071886.1) extracellular domain (Met 1-Ala 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. Predicted N terminal: Asp 17
Protein Purity	> 90 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	ACVRL1, activin A receptor type II-like 1
Research Background	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Chemical Properties

Molecular Weight

38.7 kDa (predicted); 50-55 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.