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Sodium 3-methyl-2-oxobutanoate

Catalog No. T37153 Copy Product Info
Purity: 98%
🥰Excellent
Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.

Sodium 3-methyl-2-oxobutanoate

Copy Product Info
🥰Excellent
Catalog No. T37153

Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.

Sodium 3-methyl-2-oxobutanoate
Cas No. 3715-29-5
Pack SizePriceUSA StockGlobal StockQuantity
500 mg$40-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:98%
Appearance:Solid
Color:White
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COA HNMR

Product Introduction

Bioactivity
Description
Sodium 3-methyl-2-oxobutanoate is a precursor of pantothenic acid in Escherichia coli.
In vitro
Methods: The role of sodium 3-methyl-2-oxobutanoate (α-Ketoisovaleric acid sodium) in Escherichia coli and in vivo metabolism was investigated.
Results: Sodium 3-methyl-2-oxobutanoate (α-Ketoisovaleric acid sodium) serves as a precursor of pantothenic acid in Escherichia coli. It increases the levels of α-ketoisocaproate and α-keto-β-methylvalerate, decreases the contents of their corresponding amino acids, causes an early decrease in ornithine, and a late increase in plasma arginine [1,2].
In vivo
Methods: The mechanism of action of sodium 3-methyl-2-oxobutanoate (α-Ketoisovaleric acid sodium) was investigated in rat models.
Results: Sodium 3-methyl-2-oxobutanoate (α-Ketoisovaleric acid sodium) induces convulsions in rats through GABAergic and glutamatergic mechanisms [3].
Chemical Properties
Molecular Weight138.10
FormulaC5H7NaO3
Cas No.3715-29-5
SmilesO=C(C(C(C)C)=O)[O-].[Na+]
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: Insoluble
H2O: 80.00 mg/mL (579.29 mM), Sonication is recommended.
DMSO: 40.00 mg/mL (289.65 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM7.2411 mL36.2056 mL72.4113 mL362.0565 mL
5 mM1.4482 mL7.2411 mL14.4823 mL72.4113 mL
10 mM0.7241 mL3.6206 mL7.2411 mL36.2056 mL
20 mM0.3621 mL1.8103 mL3.6206 mL18.1028 mL
50 mM0.1448 mL0.7241 mL1.4482 mL7.2411 mL
100 mM0.0724 mL0.3621 mL0.7241 mL3.6206 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Sodium 3-methyl-2-oxobutanoateSodium 3methyl2oxobutanoateSodium 3 methyl 2 oxobutanoate
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