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Methiothepin maleate

Name: Methiothepin maleate
Brand: TargetMol
SKU: T4375
Rating: 4.5 (1 reviews)

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Catalog No. T4375Cas No. 19728-88-2

Alias Metitepine

Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Methiothepin maleate

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Catalog No. T4375Alias MetitepineCas No. 19728-88-2

Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.

Pack Size	Price	Availability
10 mg	$166	35 days
25 mg	$359	35 days
50 mg	$488	35 days
100 mg	$867	35 days

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Product Introduction

Bioactivity

Description	Methiothepin maleate (Metitepine) is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors.
Targets&IC50	H5-HT7 receptor:152 nM
In vivo	The intracerebroventricular administration of aftin-4 (3–20 nmol) increased Aβ1-42, but not Aβ1-40, content in the mouse hippocampus, between 5 and 14 days after injection. Aftin-4 injection increased lipid peroxidation levels in the hippocampus, an index of oxidative stress.
Synonyms	Metitepine

Chemical Properties

Molecular Weight	472.62
Formula	C₂₄H₂₈N₂O₄S₂
Cas No.	19728-88-2
Smiles	OC(=O)\C=C/C(O)=O.CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1159 mL	10.5793 mL	21.1586 mL	105.7932 mL
5 mM	0.4232 mL	2.1159 mL	4.2317 mL	21.1586 mL
10 mM	0.2116 mL	1.0579 mL	2.1159 mL	10.5793 mL
20 mM	0.1058 mL	0.5290 mL	1.0579 mL	5.2897 mL
50 mM	0.0423 mL	0.2116 mL	0.4232 mL	2.1159 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	1.0579 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc