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Etiprednol dicloacetate

Name: Etiprednol dicloacetate
Brand: TargetMol
SKU: T31719
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31719Cas No. 199331-40-3

Alias BNP-166, BNP166, BNP 166

Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.

Etiprednol dicloacetate

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Purity: 99.74%

Catalog No. T31719Alias BNP-166, BNP166, BNP 166Cas No. 199331-40-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$112	In Stock	In Stock
5 mg	$260	In Stock	In Stock
10 mg	$390	In Stock	In Stock
25 mg	$653	In Stock	In Stock
50 mg	$928	In Stock	In Stock
100 mg	$1,260	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.74%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.
In vitro	Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production in human blood.[1]
In vivo	Etiprednol dicloacetate (0-100 μg/kg; intranasal inhalation) reduces peribronchial eosinophilia in the lungs of allergen-sensitized and challenged rats.[1] It is well-tolerated in rats and dogs at doses of up to 20 mg/kg administered orally over 28 days.[2] Etiprednol dicloacetate (0.1 μg/kg; intranasal inhalation) inhibits eosinophil accumulation in rats induced by antigen exposure.[3]
Synonyms	BNP-166, BNP166, BNP 166

Chemical Properties

Molecular Weight	485.4
Formula	C₂₄H₃₀Cl₂O₆
Cas No.	199331-40-3
Smiles	O(C(C(Cl)Cl)=O)[C@@]1(C(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0602 mL	10.3008 mL	20.6016 mL	103.0078 mL
5 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
10 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
20 mM	0.1030 mL	0.5150 mL	1.0301 mL	5.1504 mL
50 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL
100 mM	0.0206 mL	0.1030 mL	0.2060 mL	1.0301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc