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Etiprednol dicloacetate

Name: Etiprednol dicloacetate
Brand: TargetMol
SKU: T31719
Price: 112 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T31719Cas No. 199331-40-3

Alias BNP-166, BNP166, BNP 166

Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.

Etiprednol dicloacetate

🥰Excellent

Purity: 99.74%

Catalog No. T31719Alias BNP-166, BNP166, BNP 166Cas No. 199331-40-3

Pack Size	Price	Availability
1 mg	$112	In Stock
5 mg	$260	In Stock
10 mg	$390	In Stock
25 mg	$653	In Stock
50 mg	$928	In Stock
100 mg	$1,260	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.74%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Etiprednol dicloacetate (BNP-166) is a corticosteroid with anti-inflammatory activity.Etiprednol dicloacetate inhibits the accumulation of eosinophils and can be used in the study of inflammatory airway diseases such as asthma and in the treatment of Crohn's disease.
In vitro	Etiprednol dicloacetate (1 nM-1 μM) inhibits LPS-induced TNF-α production in human blood.[1]
In vivo	Etiprednol dicloacetate (0-100 μg/kg; intranasal inhalation) reduces peribronchial eosinophilia in the lungs of allergen-sensitized and challenged rats.[1] It is well-tolerated in rats and dogs at doses of up to 20 mg/kg administered orally over 28 days.[2] Etiprednol dicloacetate (0.1 μg/kg; intranasal inhalation) inhibits eosinophil accumulation in rats induced by antigen exposure.[3]
Synonyms	BNP-166, BNP166, BNP 166

Chemical Properties

Molecular Weight	485.4
Formula	C₂₄H₃₀Cl₂O₆
Cas No.	199331-40-3
Smiles	O(C(C(Cl)Cl)=O)[C@@]1(C(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (113.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0602 mL	10.3008 mL	20.6016 mL	103.0078 mL
5 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
10 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
20 mM	0.1030 mL	0.5150 mL	1.0301 mL	5.1504 mL
50 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL
100 mM	0.0206 mL	0.1030 mL	0.2060 mL	1.0301 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc