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EB-42486

Catalog No. T39972 CAS 2390475-81-5

EB-42486 is an effective and highly selective inhibitor of G2019S-<a href="/target/LRRK2" style="display: inline; color: #c13a36">LRRK2</a> with an IC50 < 0.2 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

EB-42486, CAS 2390475-81-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 172.00
5 mg	In stock	$ 347.00
10 mg	In stock	$ 545.00
25 mg	In stock	$ 997.00
50 mg	In stock	$ 1,625.00
1 mL * 10 mM (in DMSO)	In stock	$ 412.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
Targets&IC50	G2019S LRRK2:< 0.2 nM

Molecular Weight	414.473
Formula	C22H22N8O
CAS No.	2390475-81-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 245 mg/mL (591.13 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

PF-06454589 JH-II-127 URMC-099 BIX 02565 CZC-25146 hydrochloride EB-42486 CZC-54252 hydrochloride CZC-25146

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EB-42486 2390475-81-5 Autophagy LRRK2 EB 42486 inhibit EB42486 Inhibitor Leucine-rich repeat kinase 2 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.