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Glibornuride

Name: Glibornuride
Brand: TargetMol
SKU: T15385
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15385Cas No. 26944-48-9

Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.

Glibornuride

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Purity: 99.5%

Catalog No. T15385Cas No. 26944-48-9

Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	In Stock	In Stock
5 mg	$163	In Stock	In Stock
10 mg	$263	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$645	In Stock	In Stock
100 mg	$893	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.
Targets&IC50	K+-ATP channel:5.75 (pKi)
In vivo	Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) increases body weight and liver lipid peroxidation levels, while reducing serum uric acid levels in diabetic Swiss albino rats [2].

Chemical Properties

Molecular Weight	366.48
Formula	C₁₈H₂₆N₂O₄S
Cas No.	26944-48-9
Smiles	[H][C@@]12CC[C@@](C)([C@@H](O)[C@H]1NC(=O)NS(=O)(=O)c1ccc(C)cc1)C2(C)C
Relative Density.	1.3g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (682.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7287 mL	13.6433 mL	27.2866 mL	136.4331 mL
5 mM	0.5457 mL	2.7287 mL	5.4573 mL	27.2866 mL
10 mM	0.2729 mL	1.3643 mL	2.7287 mL	13.6433 mL
20 mM	0.1364 mL	0.6822 mL	1.3643 mL	6.8217 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7287 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc