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Glibornuride

Name: Glibornuride
Brand: TargetMol
SKU: T15385
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15385Cas No. 26944-48-9

Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.

Glibornuride

🥰Excellent

Purity: 99.5%

Catalog No. T15385Cas No. 26944-48-9

Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.

Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$263	In Stock
25 mg	$455	In Stock
50 mg	$645	In Stock
100 mg	$893	In Stock
1 mL x 10 mM (in DMSO)	$179	In Stock

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Batch Information

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Purity:99.5%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Glibornuride, a blocker of ATP-sensitive K+ channels (pKi: 5.75), inhibits high-affinity [3H]-glibenclamide binding with potencies corresponding to its K+ channel activity.
Targets&IC50	K+-ATP channel:5.75 (pKi)
In vivo	Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) increases body weight and liver lipid peroxidation levels, while reducing serum uric acid levels in diabetic Swiss albino rats [2].

Chemical Properties

Molecular Weight	366.48
Formula	C₁₈H₂₆N₂O₄S
Cas No.	26944-48-9
Smiles	[H][C@@]12CC[C@@](C)([C@@H](O)[C@H]1NC(=O)NS(=O)(=O)c1ccc(C)cc1)C2(C)C
Relative Density.	1.3g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (682.17 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7287 mL	13.6433 mL	27.2866 mL	136.4331 mL
5 mM	0.5457 mL	2.7287 mL	5.4573 mL	27.2866 mL
10 mM	0.2729 mL	1.3643 mL	2.7287 mL	13.6433 mL
20 mM	0.1364 mL	0.6822 mL	1.3643 mL	6.8217 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7287 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc