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MyD88-IN-4 is a MyD88 inhibitor. It exerts antiviral effects by upregulating IFN-β and demonstrates anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines. MyD88-IN-4 prevents the formation of MyD88 homodimers and interferes with its interaction with IRF3/IRF7. In a mouse model infected with VEEV TC-83, MyD88-IN-4 shows efficacy against encephalitic alphavirus infections by reducing viral replication and increasing survival rates. This compound is applicable for research on alphavirus infections, bacterial toxin-related diseases, and sepsis.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
| Description | MyD88-IN-4 is a MyD88 inhibitor. It exerts antiviral effects by upregulating IFN-β and demonstrates anti-inflammatory properties by inhibiting the production of pro-inflammatory cytokines. MyD88-IN-4 prevents the formation of MyD88 homodimers and interferes with its interaction with IRF3/IRF7. In a mouse model infected with VEEV TC-83, MyD88-IN-4 shows efficacy against encephalitic alphavirus infections by reducing viral replication and increasing survival rates. This compound is applicable for research on alphavirus infections, bacterial toxin-related diseases, and sepsis. |
| Molecular Weight | 713.02 |
| Formula | C44H64N4O4 |
| Cas No. | 1801552-15-7 |
| Smiles | N([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)[C@@H]2CC[C@@H](C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)CC2)CCCC5=CC=CC=C5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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