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Anti-IKK- alpha Antibody (4P589)
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Catalog No. TMAC-02125
Alias TCF16, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear factor NF kappa B inhibitor kinase alpha, Nuclear Factor Kappa B Inhibitor Kinase alpha, NFKBIKA, Inhibitor Of Nuclear Factor Kappa B Kinase alpha Subunit, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, IKKα, IKKalpha, IKKA, IKK1, IKK α, IKK alpha, IKK a kinase, IKK A, IKK 1, IKBKA, IkB kinase alpha subunit, IkappaB kinase, I Kappa B Kinase alpha, I Kappa B Kinase 1, Conserved helix loop ubiquitous kinase, Conserved Helix Loop Helix Ubiquitous Kinase, CHUK1, CHUK
Anti-IKK- alpha Antibody (4P589) is a Rabbit antibody targeting IKK- alpha. Anti-IKK- alpha Antibody (4P589) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-IKK- alpha Antibody (4P589)
Anti-IKK- alpha Antibody (4P589)
😃Good
Catalog No. TMAC-02125Alias TCF16, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear factor NF kappa B inhibitor kinase alpha, Nuclear Factor Kappa B Inhibitor Kinase alpha, NFKBIKA, Inhibitor Of Nuclear Factor Kappa B Kinase alpha Subunit, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, IKKα, IKKalpha, IKKA, IKK1, IKK α, IKK alpha, IKK a kinase, IKK A, IKK 1, IKBKA, IkB kinase alpha subunit, IkappaB kinase, I Kappa B Kinase alpha, I Kappa B Kinase 1, Conserved helix loop ubiquitous kinase, Conserved Helix Loop Helix Ubiquitous Kinase, CHUK1, CHUK
Anti-IKK- alpha Antibody (4P589) is a Rabbit antibody targeting IKK- alpha. Anti-IKK- alpha Antibody (4P589) can be used in FCM,ICC/IF,IHC,IP,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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| Description | Anti-IKK- alpha Antibody (4P589) is a Rabbit antibody targeting IKK- alpha. Anti-IKK- alpha Antibody (4P589) can be used in FCM,ICC/IF,IHC,IP,WB. |
| Synonyms | TCF16, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor, Nuclear factor NFkappaB inhibitor kinase alpha, Nuclear factor NF kappa B inhibitor kinase alpha, Nuclear Factor Kappa B Inhibitor Kinase alpha, NFKBIKA, Inhibitor Of Nuclear Factor Kappa B Kinase alpha Subunit, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, IKKα, IKKalpha, IKKA, IKK1, IKK α, IKK alpha, IKK a kinase, IKK A, IKK 1, IKBKA, IkB kinase alpha subunit, IkappaB kinase, I Kappa B Kinase alpha, I Kappa B Kinase 1, Conserved helix loop ubiquitous kinase, Conserved Helix Loop Helix Ubiquitous Kinase, CHUK1, CHUK |
| Ig Type | IgG |
| Clone | 4P589 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of IKK alpha on Jurkat cells lysates using anti-IKK alpha antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-IKK alpha antibody. Counter stained with hematoxylin. 3. ICC staining IKK alpha in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. Flow cytometric analysis of Hela cells with IKK alpha antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase a (IKKa), previously designated CHUK, interacts with IkB-a and specifically phosphorylates IkB-a on Ser 32 and 36, the sites that trigger its degradation. IKKa appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKa is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKa, IKKb and IKKg (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 85 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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