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Duocarmycin TM

Name: Duocarmycin TM
Brand: TargetMol
SKU: T11120
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11120 Copy Product Info

Purity: 99.15%

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Duocarmycin TM belongs to natural products, serving as a DNA alkylating agent with sequence-selective double-stranded DNA alkylation capability, featuring high cell permeability and potent antitumor activity, for targeted therapy including drug-resistant and low-proliferative tumors.

Cas No. 157922-77-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$158	In Stock	In Stock
5 mg	$396	In Stock	In Stock
10 mg	$589	In Stock	In Stock
25 mg	$945	In Stock	In Stock
50 mg	$1,280	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$416	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.15%

Appearance:Solid

Color:White

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COA HPLC LCMS HNMR

Product Introduction

Duocarmycin TM AI Summary

Duocarmycin TM demonstrates potent in vitro cellular toxicity against various cell lines, including Chinese hamster AA8, Chinese hamster UV4, murine mammary carcinoma EMT6, and human ovarian carcinoma SKOV3, with IC50 values ranging from 0.09 nM to 0.29 nM after 4 hours of compound exposure. This suggests that Duocarmycin TM has strong cytotoxic effects on these cell lines..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Duocarmycin TM belongs to natural products, serving as a DNA alkylating agent with sequence-selective double-stranded DNA alkylation capability, featuring high cell permeability and potent antitumor activity, for targeted therapy including drug-resistant and low-proliferative tumors.
Targets & IC50	CHO-AA8 cells:0.21 nM, SKOV3 cells:0.29 nM, UV4 cells:0.09 nM, EMT6 cells:0.13 nM
In vitro	Methods: BJAB and WSU-DLCL2 cells were treated with Duocarmycin TM (60 μM) for 4 days to detect its effect on tumor cell proliferation. Results: Duocarmycin TM is a cytotoxic agent that inhibits tumor cell proliferation. [1]

Chemical Properties

Molecular Weight	466.91
Formula	C₂₅H₂₃ClN₂O₅
Cas No.	157922-77-5
Smiles	COc1cc2cc([nH]c2c(OC)c1OC)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21
Relative Density.	1.389 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1417 mL	10.7087 mL	21.4174 mL	107.0870 mL
5 mM	0.4283 mL	2.1417 mL	4.2835 mL	21.4174 mL
10 mM	0.2142 mL	1.0709 mL	2.1417 mL	10.7087 mL
20 mM	0.1071 mL	0.5354 mL	1.0709 mL	5.3544 mL
50 mM	0.0428 mL	0.2142 mL	0.4283 mL	2.1417 mL
100 mM	0.0214 mL	0.1071 mL	0.2142 mL	1.0709 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc