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Duocarmycin TM

Name: Duocarmycin TM
Brand: TargetMol
SKU: T11120
Price: 158 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11120Cas No. 157922-77-5

Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.

Duocarmycin TM

🥰Excellent

Purity: 99.15%

Catalog No. T11120Cas No. 157922-77-5

Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.

Pack Size	Price	Availability
1 mg	$158	In Stock
5 mg	$396	In Stock
10 mg	$589	In Stock
25 mg	$945	In Stock
50 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$416	In Stock

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Batch Information

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Purity:99.15%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.
Targets&IC50	SKOV3 cells:0.29 nM, EMT6 cells:0.13 nM, UV4 cells:0.09 nM, CHO-AA8 cells:0.21 nM

Chemical Properties

Molecular Weight	466.91
Formula	C₂₅H₂₃ClN₂O₅
Cas No.	157922-77-5
Smiles	COc1cc2cc([nH]c2c(OC)c1OC)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21
Relative Density.	1.389 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1417 mL	10.7087 mL	21.4174 mL	107.0870 mL
5 mM	0.4283 mL	2.1417 mL	4.2835 mL	21.4174 mL
10 mM	0.2142 mL	1.0709 mL	2.1417 mL	10.7087 mL
20 mM	0.1071 mL	0.5354 mL	1.0709 mL	5.3544 mL
50 mM	0.0428 mL	0.2142 mL	0.4283 mL	2.1417 mL
100 mM	0.0214 mL	0.1071 mL	0.2142 mL	1.0709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc