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NSC-60339
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Catalog No. T16349Cas No. 70-09-7
NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.
NSC-60339
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Purity: 98.78%
Catalog No. T16349Cas No. 70-09-7
NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $74 | In Stock | In Stock | |
| 5 mg | $178 | In Stock | In Stock | |
| 10 mg | $273 | In Stock | In Stock | |
| 25 mg | $440 | In Stock | In Stock | |
| 50 mg | $592 | In Stock | In Stock | |
| 100 mg | $816 | In Stock | In Stock | |
| 200 mg | $1,080 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.78%
Appearance:solid
Color:White
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Product Introduction
NSC-60339 AI Summary
NSC-60339 exhibits a wide range of bioactivities, including potent inhibitory effects against multiple biological targets. These targets include MLL CXXC domain-DNA interaction, ALDH1A1, lipid storage modulators in Drosophila S3 cells, Influenza NS1 protein function, DNA Polymerase Beta, N370S glucocerebrosidase, JMJD2A-Tudor Domain, UBC13 Polyubiquitin, T. brucei phosphofructokinase, chronic active B-Cell receptor signaling, the phosphatase activity of Eya2, Histone Lysine Methyltransferase G9a, Rango-Importin beta complex formation, HP1-beta chromodomain interactions with methylated histone tails, Human Flap endonuclease 1 (FEN1), Polymerase Iota, Polymerase Kappa, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). It also affects the growth of Candida albicans, exerts delayed death inhibition on malarial parasite plastids, and interacts with the oncogenic and cytokinetic protein MgcRacGAP, RAD54, SUMO1-mediated protein-protein interactions, WRN Helicase, and the HIV-1 protein Vpr.
NSC-60339 stabilizes DNA duplex hairpin structures and human G-quadruplex F21T by moderately increasing their melting temperatures. The compound also shows potent antimicrobial activity against Escherichia coli, targeting strains with specific mutations or deletions linked to membrane integrity and efflux pump systems. It exhibits varying MIC values from >200000.0 nM to 12500.0 nM and inhibits the AcrA efflux pump, enhancing novobiocin-induced antibacterial activity and impacting bacterial membrane permeability and HT dye uptake.
However, despite its broad biological activity, NSC-60339 exhibits no significant antibacterial, antifungal, or cytotoxic effects in other tested strains or cells, with MIC and cytotoxic concentration (CC50) values exceeding 10000.0 nM in respective assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent. |
| Molecular Weight | 486.95 |
| Formula | C26H23ClN6O2 |
| Cas No. | 70-09-7 |
| Smiles | Clc1cc(ccc1C(=O)Nc1ccc(cc1)C1=NCCN1)C(=O)Nc1ccc(cc1)C1=NCCN1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (9.24 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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