Shopping Cart

Your shopping cart is currently empty

Bezuclastinib

Name: Bezuclastinib
Brand: TargetMol
SKU: T60976
Price: 179 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T60976Cas No. 1616385-51-3

Alias PLX 9486, CGT9486

Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.

Bezuclastinib

🥰Excellent

Purity: 99.55%

Catalog No. T60976Alias PLX 9486, CGT9486Cas No. 1616385-51-3

Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$179	-	In Stock
5 mg	$455	-	In Stock
10 mg	$728	-	In Stock
25 mg	$1,450	-	In Stock
50 mg	$2,320	-	In Stock
100 mg	$3,690	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.55%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.
Targets&IC50	c-Kit (D816V):<1 μM, c-Kit:<1 μM
Synonyms	PLX 9486, CGT9486

Chemical Properties

Molecular Weight	331.37
Formula	C₁₉H₁₇N₅O
Cas No.	1616385-51-3
Smiles	Cc1[nH]nc(C(=O)Nc2cnc3[nH]c(cc3c2)-c2ccccc2)c1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (211.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0178 mL	15.0889 mL	30.1777 mL	150.8887 mL
5 mM	0.6036 mL	3.0178 mL	6.0355 mL	30.1777 mL
10 mM	0.3018 mL	1.5089 mL	3.0178 mL	15.0889 mL
20 mM	0.1509 mL	0.7544 mL	1.5089 mL	7.5444 mL
50 mM	0.0604 mL	0.3018 mL	0.6036 mL	3.0178 mL
100 mM	0.0302 mL	0.1509 mL	0.3018 mL	1.5089 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc