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AG 555

Name: AG 555
Brand: TargetMol
SKU: T4326
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4326Cas No. 133550-34-2

Alias Tyrphostin B46, Tyrphostin AG 555

AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.

AG 555

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Purity: 99.94%

Catalog No. T4326Alias Tyrphostin B46, Tyrphostin AG 555Cas No. 133550-34-2

AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$113	In Stock	In Stock
50 mg	$172	In Stock	In Stock
100 mg	$259	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	AG 555 (Tyrphostin B46) is an EGFR tyrosine kinase inhibitor.
Targets&IC50	EGFR:0.7 μM
In vitro	Cell incubation in the presence of 30 μM AG 555 results in a selective down-regulation of the most abundant viral transcripts already 4 h after drug application. AG55 inhibits the growth of HPV16-immortalized cells. AG555 is already effective at 10 μM (IC50=6.4, respectively), and the cells remain arrested after withdrawal of the compound on day 5 as monitored on days 8 and 12.
Synonyms	Tyrphostin B46, Tyrphostin AG 555

Chemical Properties

Molecular Weight	322.36
Formula	C₁₉H₁₈N₂O₃
Cas No.	133550-34-2
Smiles	Oc1ccc(C=C(C#N)C(=O)NCCCc2ccccc2)cc1O
Relative Density.	1.273g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (124.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1021 mL	15.5106 mL	31.0212 mL	155.1061 mL
5 mM	0.6204 mL	3.1021 mL	6.2042 mL	31.0212 mL
10 mM	0.3102 mL	1.5511 mL	3.1021 mL	15.5106 mL
20 mM	0.1551 mL	0.7755 mL	1.5511 mL	7.7553 mL
50 mM	0.0620 mL	0.3102 mL	0.6204 mL	3.1021 mL
100 mM	0.0310 mL	0.1551 mL	0.3102 mL	1.5511 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc